Results 211 to 220 of about 1,079,877 (255)

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Contemporary medical therapy for heart failure with mildly reduced or preserved ejection fraction. [PDF]

Heart Fail Rev
Beavers CJ, Greene SJ.
europepmc   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Focal Myocardial Fibrosis Mimicking Hypertrophy in INOCA and the Energetic Cost of Supranormal Ejection Fraction. [PDF]

JACC Case Rep
Nguyen TH, Nakamura T, Sato A.
europepmc   +1 more source

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Artificial Intelligence in Heart Failure with Preserved Ejection Fraction. [PDF]

Diagnostics (Basel)
Li X, Xu C, Deng W, Zhang Y, Liu C, Gao L, Ji M, He Q, Wu Z, Qin S, Lin Y, Li Y.   +11 more
europepmc   +1 more source

Non‐Covalent Reversibly Photoconvertible Fluorescent Tags for Wash‐Free Protein Labeling

Advanced Science, EarlyView.
FAST proteins combined with one or two fluorogens undergo reversible fluorescence switching or photoconversion through photoisomerization. At low fluorogen concentration and high light intensity, they act as negative or positive photoswitchers and photoconvertible tags, which are promising for discriminating FAST variants.
Mrinal Mandal, Yuriy Shpinov, Aliénor Lahlou, Fivos Pham, Lina El Hajji, Ian Coghill, Eve Laureau, Marie‐Aude Plamont, Franck Perez, Thomas Le Saux, Isabelle Aujard, Arnaud Gautier, Ludovic Jullien   +12 more
wiley   +1 more source

Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. [PDF]

Eur Heart J
Reitsma TH, Savarese G, Kuźma Ł, Deo SV, Pennells L, Hageman SHJ, Holtrop J, Benson L, Conrad N, Lund LH, Kurasz A, Kaptoge S, Keene SJ, Chilala C, Pitt M, Fletcher RA, Khunti K, Piepoli M, Rossello X, Lees JS, Kavousi M, McEvoy JW, Wood AM, de Boer RA, Andersson C, Visseren FLJ, Koudstaal S, Di Angelantonio E, Dorresteijn JAN, CVD-COVID-UK/COVID-IMPACT Consortium , ESC Cardiovascular Risk Collaboration.   +30 more
europepmc   +1 more source

Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling

Advanced Science, EarlyView.
Standard cell culture supports were functionalized by laser‐structuring to generate advanced topographies tailored to skeletal muscle tissue. The physicochemical modifications of the polymeric surfaces and their interactions with cells were thoroughly investigated, confirming both safety and effectiveness in guiding muscle cell organization.
Lucas Duvert, Lorena Garcia‐Castillo, Clarissa Murru, Adrien Casanova, Daniel Ferry, Pierre Perrin, Solene Coste, Anne Bigot, Anne‐Patricia Alloncle, Frederique Magdinier, Stefano Testa   +10 more
wiley   +1 more source

Single-Cell Analysis of Human Heart Failure With Preserved Ejection Fraction. [PDF]

Circ Res
Hahn VS, Chaffin M, Simonson B, Jenkin SC, Mulligan AS, Rezaee M, Bedi KC, Margulies KB, Klattenhoff CA, Sharma K, Kass DA, Ellinor PT.   +11 more
europepmc   +1 more source