Results 261 to 270 of about 2,235,192 (340)

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Contemporary medical therapy for heart failure across the ejection fraction spectrum: The OPTIPHARM-HF registry. [PDF]

Eur J Heart Fail
Inciardi RM, Volterrani M, Savarese G, Vaduganathan M, Oriecuia C, Lombardi CM, Gussago C, Agostoni P, Ameri P, Armentaro G, Arzilli C, Aspromonte N, Attanasio A, Badagliacca R, Barbieri L, Bocchino PP, Bursi F, Cameli M, Canonero M, Campodonico JS, Capovilla T, Carluccio E, Carugo S, Castiglione V, Catapano D, Cipriani M, Correale M, D'Amario D, De Caterina R, De Ferrari GM, D'Elia E, Di Odoardo L, Emdin M, Falco L, Ferrante G, Fornaro A, Fornaro P, Guastamiglio G, Guazzi M, Iacoviello M, Imazio M, Incaminato E, La Rovere MT, Leonardi S, Maccallini M, Mandoli GE, Masarone D, Masetti M, Mazzoni A, Mazzotta M, Merlo M, Moschini L, Novarese F, Palazzuoli A, Pastore MC, Patti G, Pedretti RFE, Pidello S, Piepoli MF, Pinto G, Potena L, Raineri C, Rubbo FM, Sabatino M, Salzano A, Sciacqua A, Senni M, Severino P, Sinagra G, Sposato B, Taddei S, Valleggi A, Vignati C, Vizza D, Specchia C, Rosano G, Metra M, OPTIPHARM‐HF investigators.   +77 more
europepmc   +1 more source

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Left ventricular ejection fraction and myocardial fibrosis in sudden cardiac death. [PDF]

Europace
Silvola H, Holmström L, Pakanen L, King I, Eskuri A, Tikkanen J, Perkiömäki J, Huikuri H, Junttila J.   +8 more
europepmc   +1 more source

Atrial Fibrillation in Heart Failure Patients with Preserved or Reduced Ejection Fraction. Prognostic significance of Rhythm control strategy with Catheter Ablation

, 2019
Nicolás Vecchio
openalex   +2 more sources

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source

CTRP9 ameliorates heart failure with preserved ejection fraction by regulating lipid metabolism. [PDF]

J Transl Med
Xin J, Liu R, Deng M, Song Y, Cui Y, Gao J, Zhang B, Feng L, Mu X, Cui J, Li H, Zhu L, Sun Y, Yi W.   +13 more
europepmc   +1 more source

Rapid Steam‐Assisted Temperature Swing Adsorption for Direct Air Capture Using a Rotary Adsorber

Advanced Science, EarlyView.
This study presents a direct air capture (DAC) device based on a steam‐regeneration rotary adsorber for high‐purity CO2. Testing of the prototype demonstrates its capability for continuous and stable carbon capture with the potential to achieve ton‐scale.
Junye Wu, Yunhao Chen, Kuihua Wang, Yingjie Huo, Yanlin Chen, Quanwen Pan, Tianshu Ge   +6 more
wiley   +1 more source

Sex disparities in deep learning estimation of ejection fraction from cardiac magnetic resonance imaging. [PDF]

NPJ Digit Med
Kaur D, Shad R, Kumar A, Mathur M, Cho J, Fong R, Zakka C, Phillips C, Hiesinger W.   +8 more
europepmc   +1 more source