Results 291 to 300 of about 2,021,559 (378)

ER‐phagy Activation by AMFR Attenuates Cardiac Fibrosis Post‐Myocardial Infarction via mTORC1 Pathway

Advanced Science, EarlyView.
By catalyzing FAM134B ubiquitination and activating ER‐phagy, AMFR alleviates progressive fibrosis and cardiac dysfunction by inhibiting the mTORC1 pathway. Consequently, these findings underscore the essential role of AMFR‐driven ER‐phagy in mitigating the progression of fibrotic responses, offering a potential therapeutic target for preventing heart ...
Zhixiang Wang, Kaifan Niu, Wei Liu, Xinyun Wang, Boshen Yang, Taixi Li, Yizhi Chen, Yuanyuan Jin, Yu Chen, Yangyi Lin, Xian Jin   +10 more
wiley   +1 more source

Serial assessment of left ventricular ejection fraction for the management of heart failure: Unnecessary and unrealistic? [PDF]

Eur J Heart Fail
Palazzuoli A, Pellicori P, Cleland JGF.
europepmc   +1 more source

The Neglected Role of GSDMD C‐Terminal in Counteracting Type I Interferon Signaling

Advanced Science, EarlyView.
The C‐terminal domain of Gasdermin D (GSDMD‐CT) shows functions beyond pyroptosis. GSDMD‐CT negatively regulates IFN‐I signaling during viral infection by triggering autophagic degradation of RIG‐I and TBK1. GSDMD‐CT interacts with retinoic acid‐inducible gene‐I (RIG‐I) and tank‐binding kinase 1 (TBK1), leading to TRIM28‐mediated ubiquitination and ...
Weilv Xu, Suhui He, Wen Shi, Jinxia Xu, Shiyang Liu, Zexu Yu, Danyue Li, Qiao Jin, Yumeng Wang, Zian Zhang, Qian Lv, Yuanxiang Ge, Yunjie Li, Xinyue Li, Nan Chen, Xinyu Fu, Yang Yang, Fushan Shi   +17 more
wiley   +1 more source

Finerenone and semaglutide: Role in heart failure with reduced ejection fraction. [PDF]

World J Cardiol
Gulzar MAR.
europepmc   +1 more source

Mitochondrial Transplantation Augments the Reparative Capacity of Macrophages Following Myocardial Injury

Advanced Science, EarlyView.
Mitochondrial transplantation induces macrophage polarization toward an anti‐inflammatory M2 phenotype, enhances their reparative capacities, and facilitates mitochondrial transfer to cardiomyocytes, collectively promoting tissue repair and functional recovery post‐myocardial infarction.
Yuning Zhang, Xiaolei Sun, Yawei Jin, Kanghui Chen, Lu Zhang, Xiong Gao, Mohan Li, Ze Yuan, Jianguo Jia, Aijun Sun, Junbo Ge   +10 more
wiley   +1 more source

Dual‐Graded Microstructure Engineering for Flexible Piezoresistive Sensors with High Sensitivity and Broad Linear Range in Physiological Monitoring

Advanced Science, EarlyView.
A flexible piezoresistive pressure sensor with dual‐graded microstructures achieves both high sensitivity (69.8 kPa⁻¹) and a broad linear range up to 300 kPa (R2 = 0.997). Synergizing structural deformation and tunneling conduction, it enables rapid, stable, and accurate detection of subtle physiological signals, offering a scalable and cost‐effective ...
Ningning Bai, Dandan Xu, Zhuang Su, Gangqiang Li, Lilong He, Yanli Chen, Chengxi Guo, Linxuan Zhou, Xianming Qin, Ji Zhang, Daowei Wu, Weidong Wang   +11 more
wiley   +1 more source

Skeletal Muscle Alterations in Different Phenotypes of Heart Failure with Preserved Ejection Fraction. [PDF]

Int J Mol Sci
Vahle B, Klädtke R, Schauer A, Bowen TS, Wisløff U, Linke A, Adams V.   +6 more
europepmc   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Assessing LV Contractility Identifies Populations With Preserved Ejection Fraction at Risk of Adverse Heart Failure Outcomes. [PDF]

Circ Cardiovasc Imaging
Straw S, Brown OI, Cole CA, Lowry JE, Conning-Rowland M, Kamalathasan S, Datla S, Paton MF, Burgess R, Drozd M, Slater TA, Relton SD, Levelt E, Witte KK, Kearney MT, Cubbon RM, Gierula J.   +16 more
europepmc   +1 more source