Results 121 to 130 of about 820 (270)
Quantitative Analysis of Locus Coeruleus Neurons and Thalamic Noradrenergic Axons in a Progressive 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine Monkey Model of Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background
Parkinson's disease is mainly characterized by dopaminergic neurodegeneration in the substantia nigra pars compacta (SNc) and α‐synuclein accumulation. The locus coeruleus (LC) is also affected in Parkinson's disease and linked to some nonmotor symptoms, but the extent and timing of its degeneration remain unclear.Megan Carrillo, Nagore Hernández‐Pinedo, Josefa Zaldivar‐Diez, Isabel Pérez‐Santos, José A. Obeso, Carmen Cavada, Javier Blesa +6 morewiley +1 more sourceDynamics of Nerve Conduction Studies in Patients With Guillain–Barré Syndrome
Muscle &Nerve, EarlyView.ABSTRACT Introduction/Aims
The value of electrodiagnostic subtyping of Guillain–Barré syndrome (GBS) is still debated. This study aimed to determine the diagnostic yield, timing, and changes of the electrodiagnostic subtyping in patients with GBS in serial nerve conduction studies (NCS).Samuel Arends, Laura de Koning, Judith Drenthen, Mahova Zhu, Peter Y. K. van den Bergh, Robert M. Hadden, Nortina Shahrizaila, Ricardo C. Reisin, Satoshi Kuwabara, Senda Ajroud‐Driss, Giovanni Antonini, Claudia Balducci, Fabio A. Barroso, Thomas H. Brannagan, Jan Buermann, Carlos Casasnovas, Guido Cavaletti, Chi‐Chao Chao, Ulrich Dillmann, Mazen M. Dimachkie, Giuliana Galassi, Gerardo Gutiérrez‐Gutiérrez, Thomas Harbo, Sung‐Tsang Hsieh, Badrul Islam, Hans Katzberg, Lynette Kiers, Giorgia Mataluni, Julio Pardo, Yann Peréon, Yusuf A. Rajabally, Mark Stettner, Camiel Verhamme, Michal Vytopil, Waheed Waqar, David R. Cornblath, Bart C. Jacobs, IGOS Consortium, James M. Addington, Senda Ajroud‐Driss, Hiroshi Amino, Giovanni Antonini, Sharam Attarian, Umesh A. Badrising, Claudia Balducci, Fabio A. Barroso, Kathleen Bateman, Isabelita Bella, Luana Benedetti, Tulio Bertorini, Ratna Bhavaraju‐Sanka, Davide Binda, Thomas Brannagan, Chiara Briani, Jan Buermann, Mark Busby, Steven Butterworth, Carlos Casasnovas, Guido Cavaletti, Govind Chavada, Chi‐Chao Chao, Shan Chen, Kristl Claeys, Eugenia Conti, Jeremy S. Cosgrove, Marinos Dalakas, Philip van Damme, Efthimios Dardiotis, Amy Davidson, Ulrich Dillmann, Mazen Dimachkie, Alex Doets, Pieter van Doorn, Andoni Echaniz‐Laguna, Filip Eftimov, Karin G. Faber, Raffaella Fazio, Thomas E. Feasby, Janev Fehmi, Chris Fokke, Toshiki Fujioka, Ernesto Fulgenzi, Giuliana Galassi, Marcel P.J. Garssen, Cees J. Gijsbers, James M. Gilchrist, Job Gilhuis, Jonathan M. Goldstein, Kenneth C. Gorson, Namita Goyal, Volkan Granit, Gerardo Gutiérrez‐Gutiérrez, Ludwig Gutmann, Thomas Harbo, Hans‐Peter Hartung, James K.L. Holt, Sung‐Tsang Hsieh, Min Htut, Richard A.C. Hughes, Badrul Islam, Zhahirul Islam, Ivonne Jericó‐Pascual, Kenichi Kaida, Summer Karafiath, Hans Katzberg, Mohammad Ali Khoshnoodi, Lynette Kiers, Ruud P. Kleiweg, Norito Kokubun, Noah A. Kolb, Rinske van Koningsveld, Anneke J. van der Kooi, Hans Kramers, Krista Kuitwaard, Justin Y. Kwan, Shafeeq S. Ladha, Lisbeth Landschoff Lassen, Victoria H. Lawson, Helmar Lehmann, Luciana Leon Cejas, Linda Luijten, Michael P.T. Lunn, Fiore Manganelli, Hadi Manji, Girolama A. Marfia, Celedonio Márquez Infante, Lorena Martín‐Aguilar, Eugenia Martinez‐Hernandez, Giorgia Mataluni, Marcelo Mattiazzi, Christopher McDermott, Gregg Meekins, Quazi Deen Mohammad, Soledad Monges, Germán Moris de la Tassa, Caterina Nascimbene, Eduardo Nobile‐Orazio, Richard J. Nowak, Michael Osei‐Bonsu, Julio Pardo, Farah Pelouto, Yann Péreon, Michael T. Pulley, Luis Querol Gutiérrez, Yusuf Rajabally, Stephen W. Reddel, Taco van der Ree, Simon Rinaldi, Paolo Ripellino, Rhys C. Roberts, Iñigo Rojas‐Marcos, Stacy A. Rudnicki, George M. Sachs, Johnny P.A. Samijn, Lucio Santoro, Angelo Schenone, Maria José Sedano Tous, Yukari Sekiguchi, Kazim A. Sheikh, Nicholas Joseph Silvestri, Soeren H. Sundrup, Claudia Sommer, Beth Stein, Mark Stettner, Amro Maher Stino, Robin C.M. Thomma, Paul Twydell, Giovanni Uncini, Jay D. Varrato, Camiel Verhamme, Frederique H. Vermeij, Jan Verschuuren, Leo H. Visser, Michal Vytopil, Christa Walgaard, Min Wang, Yuzhong Wang, Waheed Waqar, Hugh J. Willison, Paul W. Wirtz, Marieke van Woerkom, Sascha A. Zivkovic +181 morewiley +1 more sourcePlatelet‐Activating Factor Pathway in Women With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity
Obesity, EarlyView.Increased hepatic PAFR expression in MASLD is associated with histological disease severity and may contribute to progression through platelet activation, whereas circulating Lp‐PLA2 levels lack discriminatory value as a noninvasive biomarker. ABSTRACT Objective
This study aimed to investigate the platelet‐activating factor (PAF) pathway in obesity ...Joan Duran‐Bertran, Helena Clavero‐Mestres, Razieh Mahmoudian, Sara Muñiz‐Piera, Carmen Aguilar, David Riesco, Javier Camaron, Salomé Martínez, Margarida Vives, Marta París, Fàtima Sabench, Teresa Auguet +11 morewiley +1 more sourceDisarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer
ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi +5 morewiley +1 more sourceEfficacy of anti-PD1 therapy in PD1-high mRNA tumors across multiple cancer types: results from cohort 1 and cohort 2 of the phase II SOLTI-1904 ACROPOLI trial. [PDF]
ESMO OpenSeguí E, Brasó-Maristany F, Pascual T, Sanfeliu E, Victoria I, Saura C, Hierro C, López-González A, Izarzugaza Y, Ciruelos E, Gavilá J, Racca F, Cejalvo JM, Amillano K, Paz-Ares L, Juan M, Felip E, Garralda E, González B, Arance A, Martín-Liberal J, Conte B, Walbaum B, Indacochea A, Castillo O, Blasco P, Pardo F, Aguirre Á, Sirenko V, González X, Galván P, Vivancos A, Ferrero-Cafiero JM, Mulero-Sánchez A, Salvador F, Villacampa G, Mesía R, Cervantes A, Prat A, Tabernero J. +39 moreeuropepmc +1 more source
