Results 191 to 200 of about 820 (270)

Early Holocene jökulhlaup chronology and deglaciation dynamics in central Iceland

open access: yesBoreas, EarlyView.
Glacial lake outburst floods (jökulhlaups) have occurred throughout the Quaternary in glaciated regions worldwide. Reconstructing flood chronology yields insight into deglaciation processes, environmental change and the role of extreme events in landscape evolution.
Greta H. Wells   +4 more
wiley   +1 more source

Late‐Holocene evolution of a small Sub‐Arctic glacier, Gljúfurárjökull (Tröllaskagi, northern Iceland)

open access: yesBoreas, EarlyView.
Gljúfurárjökull, located on the Tröllaskagi Peninsula in northern Iceland, is a small glacier approximately 3.8 km in length. This study analyses the glacier's evolution through a combination of methods including: (i) geomorphological mapping, (ii) Cosmic‐Ray Exposure (CRE) dating, (iii) lichenometry and (iv) palaeoglacier reconstruction (volume ...
Nuria Andrés   +14 more
wiley   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

open access: yesBrain Pathology, EarlyView.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga   +11 more
wiley   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

open access: yesBritish Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva   +10 more
wiley   +1 more source

Cumulative effect of multiple health and social factors on adolescent mental well‐being: a cross‐sectional study in Catalonia

open access: yesChild and Adolescent Mental Health, EarlyView.
Background While numerous studies have explored factors contributing to poor mental health, few have examined the combined influence of multiple health and social factors and their cumulative effect. This study specifically aimed to analyze the cumulative effect of multiple health and social factors associated with poor mental well‐being in school‐aged
Marina Robles‐Muñoz   +7 more
wiley   +1 more source

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