Results 41 to 50 of about 910,036 (285)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Elastic Fibers and F-Box and WD-40 Domain-Containing Protein 2 in Bovine Periosteum and Blood Vessels

open access: yesBiomimetics, 2022
Elastic fibers form vessel walls, and elastic fiber calcification causes serious vascular diseases. Elastin is a well-known elastic fiber component; however, the insoluble nature of elastic fibers renders elastic fiber component analysis difficult.
Mari Akiyama
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

On acoustic propagation in three-dimensional rectangular ducts with flexible walls and porous linings [PDF]

open access: yes, 2012
This is the post-print version of the Article. The official published version can be accessed from the links below - Copyright @ 2012 Acoustical Society of AmericaThe focus of this article is toward the development of hybrid analytic-numerical mode ...
Lawrie, JB, Jane B. Lawrie
core   +1 more source

Topologically protected steady cycles in an icelike mechanical metamaterial

open access: yesPhysical Review Research, 2021
Competing ground states may lead to topologically constrained excitations such as domain walls or quasiparticles, which govern metastable states and their dynamics. Domain walls and more exotic topological excitations are well studied in magnetic systems
Carl Merrigan   +2 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

open access: yesFEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo   +4 more
wiley   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

open access: yesAdvanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar   +2 more
wiley   +1 more source

Domain walls in helical magnets: Elasticity and pinning [PDF]

open access: yesEPL (Europhysics Letters), 2014
Recently completely new types of domain walls (DWs) have been discovered in helical magnets, consisting generically of a regular array of {\it pairs} of magnetic vortex lines \cite{Li+12}. Only for special orientations DWs are free of vortices. In this article we calculate their elastic and pinning properties, using the pitch angle $θ$ as a small ...
openaire   +2 more sources

Thermomechanical Fatigue and Creep–Fatigue Interaction of Inconel 718 Additively Manufactured by Laser Beam Powder Bed Fusion

open access: yesAdvanced Engineering Materials, EarlyView.
Thermomechanical fatigue tests of laser beam powder bed fusion (PBF‐LB) Inconel 718 show that the additively manufactured material reaches almost the lifetimes of conventionally‐rolled material under no‐dwell conditions. Introducing dwell times at the maximum temperature markedly reduces the lifetimes due to pronounced grain boundary sliding associated
Stefan Guth   +6 more
wiley   +1 more source

Effect of surrounding frame members on the buckling behavior of steel shear walls restrained by stiffeners

open access: yesJapan Architectural Review, 2020
Numerous studies have addressed the influence of the surrounding frame members on the in‐plane properties of steel shear walls with stiffeners. However, the effect of the out‐of‐plane stiffness on the buckling strength of stiffening plates has not been ...
Kikuo Ikarashi   +5 more
doaj   +1 more source

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