Results 61 to 70 of about 1,072,240 (400)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Graded titin cleavage progressively reduces tension and uncovers the source of A-band stability in contracting muscle

open access: yeseLife, 2020
The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Here, we use a novel titin-cleavage (TC) mouse model that allows specific and rapid cutting of elastic titin to quantify ...
Yong Li   +7 more
doaj   +1 more source

Thermal deformation of a long elastic strip

open access: yesRUDN Journal of Engineering Research, 2021
A general method is proposed for the formulation and solution of temperature problems of the theory of elasticity for thin-walled bodies for a given temperature distribution with the preservation of the order of differential equations and the fulfilment ...
Evgeny M. Zveryaev
doaj   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini   +11 more
wiley   +1 more source

Does Marine Surface Tension Have Global Biogeography? Addition for the OCEANFILMS Package

open access: yesAtmosphere, 2018
We apply principles of Gibbs phase plane chemistry across the entire ocean-atmosphere interface to investigate aerosol generation and geophysical transfer issues.
Scott Elliott   +19 more
doaj   +1 more source

Elastic modeling of point-defects and their interaction [PDF]

open access: yesComputational Materials Science, Elsevier, 2018, 147, pp.49 - 63, 2018
Different descriptions used to model a point-defect in an elastic continuum are reviewed. The emphasis is put on the elastic dipole approximation, which is shown to be equivalent to the infinitesimal Eshelby inclusion and to the infinitesimal dislocation loop.
arxiv   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Constitutive model of shape memory alloy under the effect of martensite plasticity for finite-element applications

open access: yesThe Journal of Engineering, 2018
This study is focused on the superelastic Ni-based shape memory alloy (SMA) for finite-element applications. SMA has presented excellent characterisations in biomedical application, mechanical application, aerospace application, seismic prevention ...
Aicheng Zou, Yanping Wang, Qidong Zhang
doaj   +1 more source

Resilience and active inference

open access: yesFrontiers in Psychology, 2022
In this article, we aim to conceptualize and formalize the construct of resilience using the tools of active inference, a new physics-based modeling approach apt for the description and analysis of complex adaptive systems. We intend this as a first step
Mark Miller   +14 more
doaj   +1 more source

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