Results 211 to 220 of about 29,969 (357)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Course script for the 2nd ELD Initiative Massive Open Online Course (MOOC) on ‘Options and pathways for action: Stakeholder Engagement’ May 5 – June 29, 2015

, 2015
Emmanuelle Quillérou, Thomas Falk
openalex   +1 more source

Effects of drawing during read aloud on ELD students

, 1999
Melinda G Nettles
openalex   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Effect of heparin and ethanol on orientation exploratory behavior of rats in the Open fi eld test

, 2020
А. Е. Хомутов, А.S. Lizunova
openalex   +1 more source

Exploratory analysis of epilepsy biomarkers using untargeted metabolomics across multiple cohorts. [PDF]

Front Neurol
Oja KT, Ilisson M, Reinson K, Muru K, Reimand T, Peterson H, Fishman D, Haller T, Kronberg J, Estonian Biobank Research Team, Wojcik MH, Kennedy AD, Sommerville L, Michelotti G, O'Donnell-Luria A, Õiglane-Shlik E, Pajusalu S, Õunap K.   +17 more
europepmc   +1 more source

The generall historie of Spaine : containing all the memorable things that haue past in the Realmes of Castille, Leon, Nauarre, Arragon, Portugall, Granado & and by what meanes they were united and so continue under Phlip the third...

Sign.: A[2.4], B-Z6, 2A-2Z6, 3A-3Z6, 4A-4Z6, 5A-5Z6, 6A-6H6, 6I8, 6K6, 6L8. -- Error de pag.: de p. 971 pasa a p. 872. -- Port. grab.
Turquet, Louis de Mayerne
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Characterization of Local Plasmons Excited by Femtosecond Laser Pulses with Dark-fi eld Correlation Imaging Microscope

, 2013
Jun Oi, Miyuki Kusaba, Keiichiro Matsuishi, Shutaro Onishi, Takuya Harada, Y. Oishi, Fumihiko Kannari   +6 more
openalex   +2 more sources

Late-onset depression predicts cognitive impairment and subsequent dementia among older adults with major depressive disorder: findings from UK Biobank and primary care linked data. [PDF]

BJPsych Open
Xue L, Bocharova M, Young AH, Aarsland D.   +3 more
europepmc   +1 more source