Results 101 to 110 of about 1,337,597 (307)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Working Paper 07-10 - The Belgian long-term care system [PDF]
This report describes the organization of the Belgian long‐term care system. It can be characterized as a mixed system with extensive public care provision and substantial support from informal care mainly within the family.
Peter Willemé
core
Technology and the Appearance of the Good: Carebots, Virtual Virtue, and the Best Possible Life [PDF]
, 2008 Growth of the elderly population and nursing shortage place increased pressure on our health care systems. One possible response is to let care robots or carebots take over care tasks.
Coeckelbergh, Mark
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
BMC Geriatrics, 2018 Background Advance Care Planning (ACP) is the repeated communication and decision-making process between the patient, family, and healthcare professionals.
Irene Aasmul +2 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Learning From History: Deinstitutionalization of People with Mental Illness as Precursor to Long-Term Care Reform [PDF]
, 2007 Considers the deinstitutionalization of state mental hospital patients over the past fifty years, and uses this as a model for evaluating reform efforts of custodial and long-term care services for the ...
Chris Koyanagi
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Long-term Care Insurance Facilities and Interregional Migration of the Elderly in Japan [PDF]
Using municipality-level data of Japan, this paper empirically examines how the capacity of long-term care insurance facilities impacts interregional migration of the elderly. We construct net-migration data of the elderly population in each municipality
Akihiro Kawase, Katsuyoshi Nakazawa
core