Results 241 to 250 of about 6,454,237 (358)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Community-Driven Development of the Chalerm App: A Mobile Health Application for Chronic Disease Management and Elderly Care in Southern Thailand. [PDF]

J Multidiscip Healthc
Lekapol A, Raksanam B, Sornkaew W, Thirarattanasunthon P, Nak-Ai W, Bunmalert A, Kraikaew R, Chuaykaew B, Munira L, Mallongi A.   +9 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The impact of an Activation-Socialisation Intervention Programme on the emotionality and loneliness of older adults in Slovak elderly care facilities: a pilot study. [PDF]

Health Psychol Rep
Ďuricová D, Ďuricová L.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Real-time activity and fall detection using transformer-based deep learning models for elderly care applications. [PDF]

BMJ Health Care Inform
Zafar RO, Zafar F.
europepmc   +1 more source

Service robots: value co-creation and co-destruction in elderly care networks

, 2018
Martina Čaić, G. Odekerken-Schröder, D. Mahr   +2 more
semanticscholar   +1 more source

Impacts of robot implementation on care personnel and clients in elderly-care institutions

Int. J. Medical Informatics, 2019
H. Melkas, L. Hennala, Satu Pekkarinen, Ville Kyrki   +3 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Impact of Music Interventions on Depression in Care Home Residents with Dementia: UK Results from Music Interventions for Depression and Dementia in Elderly Care RCT. [PDF]

Geriatrics (Basel)
Schneider J, Ablewhite J, Bloska J, Orrell M, Odell-Miller H, Assmus J, Gold C, Sveinsdottir V.   +7 more
europepmc   +1 more source