Results 61 to 70 of about 1,481,214 (358)

Phase II study of durvalumab (MEDI 4736) plus carboplatin and etoposide in elderly patients with extensive stage small cell lung cancer: Study protocol of turtle study (LOGIK 2003)

Thoracic Cancer, 2023
Background Recently, the addition of antiprogrammed cell death‐ligand 1 (PD‐L1) monoclonal antibodies, including durvalumab and atezolizumab to platinum‐based chemotherapy, has demonstrated clinical benefits in patients with untreated advanced small cell
Hidenobu Ishii, Koichi Azuma, Takayuki Shimose, Hiroshige Yoshioka, Takayasu Kurata, Naoki Shingu, Masaki Okamoto, Yosuke Kawashima, Isamu Okamoto   +8 more
doaj   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan, Damien Faury, Alexander G. Weil, Harrison J. Westwick, Nada Jabado, Sébastien Perreault   +5 more
wiley   +1 more source

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources

Median Effective Dose of Dexmedetomidine Inducing Bradycardia in Elderly Patients Determined by Up-and-Down Sequential Allocation Method [PDF]

, 2022
Hua Yang, Yu Fu, Fang Deng, Yun Shao, Yugang Lu, Jin‐Chao Song   +5 more
openalex   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Assessment of risk for falls in elderly [PDF]

Opšta Medicina, 2014
Introduction: Elderly persons have higher risk for falls, compared to younger population. Although no single risk factor causes all falls, a great deal of risk factors to which an individual is exposed, i.e.
Stanetić Kosana, Marković Brankica, Tešanović Gordana, Savić Suzana, Šukalo Mladen, Kremenović Zora   +5 more
doaj   +1 more source

Anaemia in elderly patients [PDF]

Clinical Medicine, 2007
Anaemia is independently associated with mortality and loss of physical function in elderly subjects, even with haemoglobin levels currently considered to be within the lower end of the normal range Chronic disease and iron deficiency anaemia are the most common causes of anaemia in older people A ferritin level below 45 μg/l should be used as a cut ...
Graham Mulley, Peter Crome, Lesley McCormick, David J Stottmbchb   +3 more
openaire   +2 more sources

Depression Among the Elderly: Screening Practices and Attitudes Among Nurse Practitioners [PDF]

, 2009
Purpose: To examine California\u27s nurse practitioners\u27 (NPs) screening practices and attitudes towards depression among the elderly using the Depression Attitude Questionnaire (DAQ) (Botega, Mann, Blizard, & Wilkinson, 1992).
Le, Grace
core   +1 more source

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source

Colonoscopy in Patients Aged 85 Years or Older: An Observational Study

Journal of the Anus, Rectum and Colon, 2018
Objectives: Colonoscopy is the first-line modality to examine the colon even in the very elderly but may have an increased risk of complications. This study aimed to evaluate the efficacy and safety of colonoscopy in the very elderly.
Noriyuki Isohata, Rieko Shimojima, Kenichi Utano, Daiki Nemoto, Shungo Endo, Hiroyuki Kato, Daisuke Takayanagi, Masato Aizawa, Tetsutaro Nemoto, Alan Kawarai Lefor, Kazutomo Togashi   +10 more
doaj   +1 more source