Results 51 to 60 of about 6,463 (245)

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Patients' characteristics and 30-day mortality for those undergoing elective surgeries during the COVID-19 pandemic in Bangladesh.

PLoS ONE, 2023
BackgroundThe COVID-19 pandemic has significantly impacted the surgical practice throughout the world, including elective surgical care. This study investigated the characteristics of patients undergoing elective surgery, the prevalence of COVID-19 ...
Shakera Ahmed, Anwarul Karim, Tanvir Kabir Chowdhury, Orindom Shing Pulock, Nowrin Tamanna, Mastura Akter, Puja Biswas, Fahmida Afroz, Susmita Dey Pinky, Anika Nahrin Alabbi, Tasnuba Raisa Jamil, Zarin Tasnim, Dipa Dev, Mraching Marma, Tasmiah Tahera Aziz, Hafiz Ahmed Nazmul Hakim, A K M Khairul Basher, Nur Hossain Bhuiyan Shahin, Tahmina Banu   +18 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Safety of maintaining elective and emergency surgery during the COVID-19 pandemic with the introduction of a Protected Elective Surgical Unit (PESU): A cross-specialty evaluation of 30-day outcomes in 9,925 patients undergoing surgery in a University Health Board

Surgery Open Science, 2022
Background: The COVID-19 pandemic has caused unprecedented health care challenges mandating surgical service reconfiguration. Within our hospital, emergency and elective streams were separated and self-contained Protected Elective Surgical Units were ...
T Minto, MBChB, T Abdelrahman, MD, L Jones, MBA, J Wheat, FRCS, T Key, MBChB, N Shivakumar, MBChB, J Ansell, MD, O Seddon, MBBCh, A Cronin, FRCS, A Tomkinson, FRCS, A Theron, FRCA, RW Trickett, MD, N Sagua, S Sultana, A Clark, E McKay, A Johnson, Karishma Behera, J Towler, H Kynaston, MD, A Mohamed, G Blackshaw, R Thomas, S Jones, M Shinkwin, H Perry, D Edgbeare, S Chopra, L DaSilva, I Williams, U Contractor, S Bell, S Zaher, M Stechman, S Berry, H Clark, E Bois, C Von Oppell, L Ackerman, E Ablorsu, J Horwood, D Mehta, J Featherstone, E Folaranmi, M Bray, K Siddall, E King, M Phillips, J Morgan, I Chopra, D Evans, K Whitehouse, P Leach, C Thomas, E Davies, M Dyer, A Fox, E Ireland, E Meehan, A Mukit, K Newell, D Parry, B Popham, C Chapman, H Botros   +64 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Normal Appendix in the Elective Inguinal Hernia Repair: Case Report and Review of Literature

Gazeta Médica, 2019
INTRODUCTION: The presence of the vermiform appendix in an inguinal hernial sac is known as an Amyand’s hernia. In the elective hernia repair, this represents a rare finding and the decision to perform appendectomy is always ambiguous.
João Miguel Carvas, Lília Meireles, Diego P Perez, João Pinto-de-Sousa, Cátia Canelas   +4 more
doaj   +1 more source

QUEUE PROFILE FOR PEDIATRIC SCOLIOSIS SURGERY IN A REFERENCE HOSPITAL IN THE BRAZIL’S MIDWEST

Coluna/Columna, 2023
Objective: To describe the epidemiological profile of the list of patients with pediatric scoliosis (0 to 18 years old) treated at a tertiary public hospital in the Midwest Region.
SINVAL DORNELES FILHO, MURILO TAVARES DAHER, MATEUS BERGAMO LOMAZ, LUCAS LODOMIRO MELO, JULIANE LEITE ORCINO, NATHALIA AIDAR BITTAR, GABRIEL JOãO FRANCISCO DE SOUZA, THIAGO VINíCIUS DE ASSIS MORAES, PEDRO FELISBINO JúNIOR, PAULO HENRIQUE MARTINS SILVA   +9 more
doaj   +1 more source

Use of routinely collected national data sets for reporting on induced abortion in Australia [PDF]

, 2005
Foreword The lack of national data on induced abortion in Australia represents a gap in health statistics. The AIHW’s Reproductive Health Indicators in Australia 2002 report included an indicator on induced abortions in Australia, but national data were
Jenny Hargreaves, Elizabeth A. Sullivan, Narelle Grayson   +2 more
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