Results 41 to 50 of about 308,095 (334)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Novel TCAD oriented definition of the off-state breakdown voltage in Schottky-gate FETs: a 4H SiC MESFET case study [PDF]

, 2008
Physics-based breakdown voltage optimization in Schottky-barrier power RF and microwave field-effect transistors as well as in high-speed power-switching diodes is today an important topic in technology computer-aided design (TCAD).
Bonani, Fabrizio, Furno, M., Ghione, Giovanni   +2 more
core   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Performance limiting effects in X-band accelerators

Physical Review Special Topics. Accelerators and Beams, 2011
Acceleration gradient is a critical parameter for the design of future TeV-scale linear colliders. The major obstacle to higher gradient in room-temperature accelerators is rf breakdown, which is still a very mysterious phenomenon that depends on the ...
Faya Wang, Chris Adolphsen, Christopher Nantista   +2 more
doaj   +1 more source

Air breakdown characteristics in plane-plane and sphere gap electrode configuration under lightning impulse [PDF]

, 2014
This report describes the air breakdown characteristics in plane-plane and sphere gap electrode configuration under lightning impulse. The breakdown in air (spark breakdown) is the transition of a non-sustaining discharge into a self sustaining ...
Rosdi, Hairierosniza
core  

Polydatin ameliorates ovalbumin‐induced asthma in a rat model through NCOA4‐mediated ferroautophagy and ferroptosis pathway

FEBS Open Bio, EarlyView.
In this research, a rat model of asthma was created using OVA, and polydatin served as an intervention. By inhibiting ferroautophagy mediated by NCOA4 and averting ferroptosis, polydatin has been demonstrated to reduce asthma. This work presents new ideas for investigating the mechanism of polydatin's ability to alleviate asthma, in addition to ...
Wei Li, Yuwei Tang, Wenkang Liu, Fang Fang, Jiepeng Wang, Chaoyi Fang   +5 more
wiley   +1 more source

Avalanches in Breakdown and Fracture Processes

, 1999
We investigate the breakdown of disordered networks under the action of an increasing external---mechanical or electrical---force. We perform a mean-field analysis and estimate scaling exponents for the approach to the instability.
A. A. Griffith, A. Buchel, A. Buchel, A. Garcimartín, A. Guarino, A. H. Thompson, A. Hansen, A. Hansen, A. Petri, Alessandro Vespignani, B. Gutenberg, B. K. Chakrabarti, B. Kahng, B. Suki, C. Maes, C. Unger, C. Unger, D. Heerman, D. Sornette, F. Tzschichholz, G. Caldarelli, G. Cannelli, G. Vasconcelos, H. A. Daniels, H. Eugene Stanley, J. B. Rundle, J. B. Rundle, J. B. Rundle, J. D. Gunton, J. P. Sethna, J. Weiss, K. Dahmen, K.-T. Leung, K.-T. Leung, L. de Arcangelis, L. de Arcangelis, L. Golubovic, L. Golubovic, L. Monette, L. Monette, M. Acharaya, M. Acharaya, M. Kloster, P. C. Hemmer, P. Diodati, P. Duxbury, P. Ray, Purusattam Ray, R. Englman, R. L. B. Selinger, R. L. B. Selinger, S. Ciliberto, S. Field, S. Kirkpatrik, S. L. Phoenix, S. Roux, S. Zapperi, S. Zapperi, S. Zapperi, Stefano Zapperi, T. Ray, V. I. Räisänen, W. H. Press, Z.-G. Wang   +63 more
core   +1 more source

Electrical breakdown phenomena of dielectric elastomers [PDF]

SPIE Proceedings, 2017
Silicone elastomers have been heavily investigated as candidates for dielectric elastomers and are as such almost ideal candidates with their inherent softness and compliance but they suffer from low dielectric permittivity. This shortcoming has been sought optimized by many means during recent years.
Yu, Liyun, Mateiu, Ramona Valentina, Skov, Anne Ladegaard   +2 more
openaire   +5 more sources

Discovery and Treatment of Action Potential‐Independent Myotonia in Hyperkalemic Periodic Paralysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hyperkalemic periodic paralysis (hyperKPP) is characterized by attacks of transient weakness. A subset of hyperKPP patients suffers from transient involuntary contraction of muscle (myotonia). The goal of this study was to determine mechanisms causing myotonia in hyperKPP.
Chris Dupont, Adam Deardorff, Murad Nawaz, Andrew A. Voss, Mark M. Rich   +4 more
wiley   +1 more source

High-gradient behavior of a dipole-mode rf structure

Physical Review Accelerators and Beams, 2020
A normal-conducting, X-band traveling wave structure operating in the dipole mode has been systematically high-gradient tested to gain insight into the maximum possible gradients in these types of structure.
B. Woolley, G. Burt, A. C. Dexter, R. Peacock, W. L. Millar, N. Catalan Lasheras, A. Degiovanni, A. Grudiev, G. Mcmonagle, I. Syratchev, W. Wuensch, E. Rodriguez Castro, J. Giner Navarro   +12 more
doaj   +1 more source