Results 121 to 130 of about 1,235,726 (301)

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

IMPROVING DURABILITY OF ELECTRIC SUBMERSIBLE PUMP UNITS

This article is devoted to researching ways to increase the reliability, strength, and overall service life of Electric Submersible Centrifugal Pump (ESCP) Units.
A.N. Orakova, P.A. Tanzharikov
core   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Vibration Problems With An Electric Motor For A Centrifugal Pump Installation

, 1993
Lecturepg. 97A case history is presented in which vibration related problems with two pole electric motors have delayed acceptance of the complete pump packages by the end user.
Wray, Lawrence
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

ISSN 2347-9523 (Print) Variable Rotational Speed Influence to Internal Flow Field of Electric Submersible Pump with CFD

, 2015
: To study the impact of variable speed operation to electric submersible pump internal flow field, the fluid dynamics numerical simulation for impeller passages is accomplished under five kinds of rotational speed.
Hui-Bin Gu, Ye Yuan, Huan-Huan Ding
core  

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Multirobot Aerial Soft Manipulator for Floating Litter Collection

Advanced Intelligent Systems, EarlyView.
A multirobot aerial manipulator enables autonomous floating litter collection by controlling the shape of a flexible rope equipped with a hook‐based tool. Adaptive rope‐shape planning enhances grasping performance while reducing tension, demonstrating the potential of aerial robots for floating litter removal. Removing floating litter from water bodies
Antonio González‐Morgado, Sander Smits, Guillermo Heredia, Anibal Ollero, Alexandre Krupa, François Chaumette, Fabien Spindler, Antonio Franchi, Chiara Gabellieri   +8 more
wiley   +1 more source

EVALUASI REDESAIN ELECTRIC SUBMERSIBLE PUMP (ESP) PADA SUMUR “X” LAPANGAN “Y” [PDF]

, 2012
Sumur “X” merupakan salah satu sumur di lapangan “Y” yang sudah mengalami penurunan tekanan sehingga produksinya perlu ditingkatkan. Penurunan produksi tersebutlah yang menjadi alasan dilakukannya evaluasi Electric Submersible Pump untuk memperoleh laju ...
NOVY HUSNI , MUBARROQ
core