Results 171 to 180 of about 120,375 (305)

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

open access: yesAdvanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang   +27 more
wiley   +1 more source

Microglial GPR35 Ameliorates Epileptogenesis and Neuroinflammation via PDGFA Domain 2 Signaling

open access: yesAdvanced Science, EarlyView.
Activation of microglial G protein–coupled receptor 35 (GPR35) by L‐kynurenic acid (L‐Kyna) initiates a platelet‐derived growth factor A (PDGFA)–dependent phosphoinositide 3‐kinase–protein kinase B (PI3K–AKT) signaling cascade that dampens hippocampal neuroinflammation, thereby restraining epileptogenesis, lowering seizure susceptibility, and ...
Qi Wang   +17 more
wiley   +1 more source

Non‐Volatile Phase Modulation with Ultralow Energy Consumption Enabled by 2D Ferroelectric/TMD Heterostructures

open access: yesAdvanced Science, EarlyView.
We demonstrate a hybrid WS2/CuInP2S6/graphene heterostructure integrated on a silicon nitride microring resonator for non‐volatile optical phase modulation with ultra‐low energy consumption and low insertion loss. While CIPS alone does not provide efficient optical index modulation, the engineered proposed device structure converts ferroelctric domain ...
Lalit Singh   +10 more
wiley   +1 more source

From Design to Prototype: High‐Sensitivity Tri‐Mode Operation Photodetectors Based on 1T‐2H Hybrid MoS2

open access: yesAdvanced Science, EarlyView.
This work demonstrates a phase‐engineered MoS2 photodetector that dynamically switches among photocapacitive (PCC), photovoltaic (PV), and photoconductive (PC) modes. By transforming the traditionally parasitic capacitance into an active signal source, the device achieves self‐powered, high‐sensitivity detection with a fast response of 19.2 ms, and a ...
Xinyu Li   +16 more
wiley   +1 more source

Analog Signal Summation for Reinforcement Learning via Simultaneous Light–Voltage Modulation in a Synaptic Device

open access: yesAdvanced Science, EarlyView.
To overcome limitations of conventional AI hardware, a light‐voltage dual‐modulating synaptic (LVDS) transistor using an IGZO/InAs quantum dot hybrid structure is proposed. LVDS transistor enables analog summation for Dueling Deep Q‐Networks by independently modulating memory via optical and electrical stimuli.
Dong Gue Roe   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy