Results 251 to 260 of about 128,859 (312)

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Hybrid reinforcement learning optimization of aging aware energy management and powertrain sizing in fuel cell hybrid electric vehicles. [PDF]

Sci Rep
Mostashiri A, Montazeri-Gh M.
europepmc   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

DLLT: A dual-layer LSTM-transformer model for real-time energy and dynamics prediction in plug-in hybrid electric vehicles. [PDF]

PLoS One
Zhang X, Chen Z, Fang X.
europepmc   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Machine learning-based MPPT integration with quadratic double-extended DC-DC converter for grid-connected PV-powered BLDC electric vehicles. [PDF]

Sci Rep
Karthikeyan D, Shukla VK, Rajesh K.
europepmc   +1 more source

Experimental optimization of an IoT-driven load adaptive wireless charging system for electric vehicles using response surface methodology. [PDF]

Sci Rep
Nandankar PV, Chaturvedi A, Akram PS, SivaramKrishnan M, Jayabalan SK, Jelila YD, Ghouse M, Khan TMY.   +7 more
europepmc   +1 more source

A proposed reinforcement learning approach via discrete control reformulation and multi-step double DQN for adaptive cruise control in electric vehicles. [PDF]

Sci Rep
Meghawer A, El-Shaer Y, El-Sebah MIA, El-Khatib MF.   +3 more
europepmc   +1 more source

Dimensionality-reduced multi-objective framework for resilient power systems with electric vehicles and hydrogen-based energy storage. [PDF]

Sci Rep
Refaat MM, Al-Dhaifallah M, Ismail MM, AbouOmar MS, El Ferik S.   +4 more
europepmc   +1 more source

Retraction: AI-assisted design of lightweight and strong 3D-printed wheels for electric vehicles. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source