Results 91 to 100 of about 43,994 (251)

Phasic firing and coincidence detection by subthreshold negative feedback: divisive or subtractive or, better, both [PDF]

, 2017
Phasic neurons typically fire only for a fast-rising input, say at the onset of a step current, but not for steady or slow inputs, a property associated with type III excitability.
Huguet Casades, Gemma, Meng, Xiangying, Rinzel, John   +2 more
core   +2 more sources

Advances in the Treatment of Sensorineural Hearing Loss: From Traditional Therapies to Stem Cell and Gene Therapies

Advanced Sensor Research, Volume 5, Issue 4, April 2026.
Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically examines current therapeutic strategies for sensorineural hearing loss, including traditional drug and physical therapies as well as emerging stem cell and gene therapies, providing a ...
Ruirui Chen, Yang Zhang, Zhe Li, Renjie Chai   +3 more
wiley   +1 more source

Predictors for estimating subcortical EEG responses to continuous speech.

PLoS ONE
Perception of sounds and speech involves structures in the auditory brainstem that rapidly process ongoing auditory stimuli. The role of these structures in speech processing can be investigated by measuring their electrical activity using scalp-mounted ...
Joshua P Kulasingham, Florine L Bachmann, Kasper Eskelund, Martin Enqvist, Hamish Innes-Brown, Emina Alickovic   +5 more
doaj   +1 more source

Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs

Neurobiology of Disease, 2007
Based on in vitro studies, it is hypothesized that neurotrophic factor deprivation following deafferentation elicits an oxidative state change in the deafferented neuron and the formation of free radicals that then signal cell death pathways.
Jun Maruyama, Takahiko Yamagata, Mats Ulfendahl, Göran Bredberg, Richard A. Altschuler, Josef M. Miller   +5 more
doaj   +1 more source

The connections of the inferior colliculus and the organization of the brainstem auditory system in the greater horseshoe bat (Rhinolophus ferrumequinum) [PDF]

, 1981
The connections of the inferior colliculus, the mammalian midbrain auditory center, were determined in the greater horseshoe bat (Rhinolophus ferrumequinum), using the horseradish peroxidase method.
Adams, Adams, Aitkin, Aitkin, Aitkin, Aitkin, Aitkin, Baron, Beyerl, Boyd, Brown, Browner, Bruns, Carey, Edwards, Elverland, Fernandez, FitzPatrick, Friend, Graham, Grinnell, Harnischfeger, Harrison, Harrison, Henkel, Henson, Henson, Illing, Irving, Jen, Kawamura, Masterton, Merzenich, Mesulam, Moore, Moore, Moushegian, Neuweiler, Neuweiler, Noda, Ollo, Osen, Ostwald, Poljak, Poljak, Pollak, Pollak, Powell, RoBarts, Rose, Roth, Schnitzler, Schober, Schroeder, Schuller, Schuller, Schweizer, Schweizer, Strominger, Suga, Suga, Suga, Tsuchitani, van Noort, Vater, Warr, Webster, Ziesmer, Zook, Zook, Zook   +70 more
core   +1 more source

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

A full-custom fully implantable cochlear implant system validated in vivo with an animal model

Communications Engineering
Realizations of fully implantable cochlear implants (FICIs) for providing adequate solution to esthetic concerns and frequent battery replacement have lacked of addressing system level criteria as a complete device.
Hasan Uluşan, M. Berat Yüksel, Özlem Topçu, H. Andaç Yiğit, Akın M. Yılmaz, Mert Doğan, Nagihan Gülhan Yasar, İbrahim Kuyumcu, Aykan Batu, Nebil Göksu, M. Birol Uğur, Haluk Külah   +11 more
doaj   +1 more source

Genetic Diagnosis and Discovery Enabled by Large Language Models

Advanced Science, Volume 13, Issue 22, 17 April 2026.
We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu, Khaled Saab, Weida Liu, Zhouqing Fang, Zhuanfen Cheng, Svetolik Spasic, Maja Djurisic, Hiroaki Mohri, Wenlong Ren, Anil Palepu, Juraj Gottweis, Alan Karthikesalingam, Kavita Kulkarni, Annalisa Pawlosky, Devon Bonner, Elijah Kravets, Shruti Marwaha, Hector R. Mendez, Matthew T. Wheeler, Jonathan A. Bernstein, Undiagnosed Diseases Network, Cheng‐Yu Tsai, Chen‐Chi Wu, Konstantina M. Stankovic, Vivek Natarajan, Gary Peltz   +25 more
wiley   +1 more source

Signaled two-way avoidance learning using electrical stimulation of the inferior colliculus as negative reinforcement: effects of visual and auditory cues as warning stimuli

Brazilian Journal of Medical and Biological Research, 1998
The inferior colliculus is a primary relay for the processing of auditory information in the brainstem. The inferior colliculus is also part of the so-called brain aversion system as animals learn to switch off the electrical stimulation of this ...
A.C. Troncoso, G. Cirilo-Júnior, G. Sandner, M.L. Brandão   +3 more
doaj   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source