Results 41 to 50 of about 2,915 (260)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Application of Electrical Resistivity Tomography for Detecting Root Biomass in Coffee Trees

International Journal of Geophysics, 2013
Roots play an important role in plants and are responsible for several functions; among them are anchorage and nutrient and water absorption. Several methodologies are being tested and used to study plant root systems in order to avoid destructive root ...
Carlos Mauricio Paglis
doaj   +1 more source

Electrical Resistivity Tomography and Vertical Sounding for Groundwater Potentials in Erhoike Community, Delta State, Nigeria

Journal of Applied Sciences and Environmental Management, 2023
This study investigated the Electrical Resistivity Tomography (ERT) A geophysical investigation involving Electrical Resistivity Tomography (ERT) and Vertical Electrical Sounding (VES) for groundwater potentials in Erhoike Community, Delta State ...
O.S. Marere, E. Dio, S. O. Iwhiwhu
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Thalamo‐Lesional Connectivity Signatures of Bilateral Tonic–Clonic Seizures in Focal Cortical Dysplasia‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Focal cortical dysplasia (FCD) is the most common etiology of drug‐resistant epilepsy in children. Focal to bilateral tonic–clonic seizures (FBTCS) mark a high risk of drug‐resistant epilepsy and involve thalamocortical circuitry in their generation and propagation.
Hua Xie, Xiaotong Li, Venkata Sita Priyanka Illapani, Leigh N. Sepeta, Jason Schroeder, Chima O. Oluigbo, Madison M. Berl, William D. Gaillard, Nathan T. Cohen   +8 more
wiley   +1 more source

SHALLOW SUBSURFACE STRUCTURES AND QUATERNARY DEFORMATIONS ON THE EASTERNMOST MATANO FAULT, INDONESIA, REVEALED BY ELECTRICAL RESISTIVITY TOMOGRAPHY

Rudarsko-geološko-naftni Zbornik
In active fault studies, electrical resistivity tomography (ERT) with wide electrode spacing (10 m) and fewer than 60 electrodes is typically utilized. However, this configuration limits the ability of ERT to resolve detailed geological information, such
Adi Patria, Muhammad Hanif, Danny Hilman Natawidjaja, Mudrik Rahmawan Daryono   +3 more
doaj   +1 more source

2D electrical resistivity tomographies for investigating recent activation landslides in Basilicata Region (Southern Italy)

Annals of Geophysics, 2008
The results of a geoelectrical survey in the study of recent activation landslides in the Lucanian Apennine chain (Southern Italy) are discussed in this paper.
L. Telesca, A. Perrone, A. Loperte, V. Lapenna, G. Colangelo   +4 more
doaj   +1 more source

2D and 3D Resistivity Imaging for Soil Site Investigation [PDF]

Engineering and Technology Journal, 2014
Electrical Resistivity Imaging (ERI) method is one of the most promisingtechniques which is well suited to applications in the fields of geohydrology,environmental science and engineering. The present work is aimed to show the efficiency of 2D Electrical
Hussein H. Karim, Mahmoud R. AL- Qaissy, Nadia A. Aziz   +2 more
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source