Results 231 to 240 of about 90,766 (269)

REIMAGINE: A central nervous system basket trial showing safety and efficacy of vafidemstat on aggression in different psychiatric disorders

open access: yesPsychiatry and Clinical Neurosciences, Volume 79, Issue 5, Page 257-265, May 2025.
Aim Vafidemstat is a brain‐penetrant, orally bioavailable, small molecule irreversible inhibitor of the histone lysine‐specific demethylase KDM1A (also known as LSD1), which corrects memory deficits and behavior alterations including aggression and social interaction deficits in preclinical models.
Marc Ferrer   +9 more
wiley   +1 more source

Vesiculation as potential novel pathogenic mechanism in autoimmune hemolytic anemia

open access: yesTransfusion, EarlyView.
Abstract Background Autoimmune hemolytic anemia (AIHA) is typically mediated by immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies, and more rarely by immunoglobulin A (IgA). The mechanism of red blood cell (RBC) destruction in IgA‐mediated AIHA is not well understood.
Esther C. W. de Boer   +14 more
wiley   +1 more source

Effects of the angle of head‐down tilt on dynamic cerebral autoregulation during combined exposure to cephalad fluid shift and mild hypercapnia

open access: yesExperimental Physiology, EarlyView.
Abstract Astronauts experience combined exposure to a cephalad fluid shift and mild hypercapnia during space missions, potentially contributing to health problems. Such combined exposure may weaken dynamic cerebral autoregulation. The magnitude of cephalad fluid shift varies between individuals, and dynamic cerebral autoregulation may be affected more ...
Tomokazu Kato   +2 more
wiley   +1 more source

Setting sail for Paris 2024: Retrospective analysis of world‐class ILCA 7 Olympic sailors’ cardiorespiratory fitness (2015–2020)

open access: yesExperimental Physiology, EarlyView.
Abstract The aim of this retrospective analysis was to provide a more comprehensive understanding of the cardiorespiratory profile of world‐class ILCA‐7 sailors (n = 3, all males), through a longitudinal evaluation offering real‐world data on physiological profile and exercise intensity domains. The cardiopulmonary exercise testing (CPET) was performed
Damir Zubac   +2 more
wiley   +1 more source

Unusual Complications in Cocaine Stuffers: A Case Report. [PDF]

open access: yesClin Pract Cases Emerg Med
Al-Balushi H   +6 more
europepmc   +1 more source

Cerebrovascular pulsatility following long duration spaceflight is associated with changes in pulse pressure and carotid artery stiffness

open access: yesExperimental Physiology, EarlyView.
Abstract Central artery stiffening increases the haemodynamic pulsations transmitted downstream towards target organs, including the brain. While recent evidence suggests that long duration spaceflight is associated with reduced common carotid artery (CCA) distensibility, cerebrovascular pulsatility has not been extensively characterized in astronauts.
Roxanne Fournier   +5 more
wiley   +1 more source

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