Results 71 to 80 of about 106,216 (305)

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Electrocardiography monitoring system and method [PDF]

, 2015
Systems and methods for electrocardiography monitoring use multiple capacitive sensors in order to determine reliable measurements of electrophysiological information of a patient.
Serteyn, Aline, Meftah, M., Vullings, Rik; id_orcid, Atallah, Louis Nicolas, Schellekens, M., Bergmans, Jan   +5 more
core   +7 more sources

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

The inverse problem of electrocardiography [PDF]

, 2011
In very broad terms, the inverse problem of electrocardiography may be deined as the determination of the electrical function of the heart from a number of remote recordings of potentials on some noninvasive or minimally invasive surface.
Cheng, Leo, Brookes, DH, Ghodrati, A, Nash, Martyn, Macleod, RS, Pullan, Andrew   +5 more
core   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Signal-averaged electrocardiography: Past, present, and future [PDF]

, 2018
Signal-averaged electrocardiography records delayed depolarization of myocardial areas with slow conduction that can form the substrate for monomorphic ventricular tachycardia.
Kolettis, T.M., Tousoulis, D., Gatzoulis, K.A., Tsiachris, D., Sideris, S., Antoniou, C., Arsenos, P., Trachanas, K., Dilaveris, P.   +8 more
core  

High Frequency Electrocardiography Signal Acquisition and Impact on Heart Rate Variability [PDF]

, 2019
Heart rate variability is an emergent fiducial marker that has demonstrated high versatility as a diagnostic and prognostic tool for reflecting autonomic nervous system function.
Belinda Schwerin, Richards, Brent, McConnell, Meghan, So, Stephen, de Mezieres, Celeste, Schwerin, Belinda, Meghan McConnell, Stephen So, Celeste de Mezieres, Brent Richards   +9 more
core   +1 more source

The long-term effects of blood urea nitrogen levels on cardiovascular disease and all-cause mortality in diabetes: a prospective cohort study

BMC Cardiovascular Disorders
Background The long-term effects of blood urea nitrogen(BUN) in patients with diabetes remain unknown. Current studies reporting the target BUN level in patients with diabetes are also limited.
Hongfang Liu, Xiaoqin Xin, Jinghui Gan, Jungao Huang   +3 more
doaj   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

‘Too Close to Eat?’ Exploring Consumer Responses to Edible Packaging Through the Lens of Food Neophobia and Construal Level Theory

Business Strategy and the Environment, EarlyView.
ABSTRACT The rapid growth of packaging waste has recently intensified the search for sustainable alternatives. Edible packaging, developed from biodegradable materials safe for consumption, represents a promising innovation that combines environmental responsibility with food preservation.
Donata Tania Vergura, Cristina Zerbini, Settimio Ziccarelli   +2 more
wiley   +1 more source