Results 1 to 10 of about 489,830 (307)

Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia and associated LUTS

Continence, 2023
This review summarises the presentations during a workshop session entitled “The Use of Soluble Guanylate Cyclase Activators to Treat Benign Prostatic Hyperplasia, Obstruction and Fibrosis – Mechanistic Concepts and Clinical Implications” at the ...
A.J. Kanai, K.-E. Andersson, L.A. Birder, C.H. Fry   +3 more
doaj   +1 more source

TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors

Nature Communications
Genome-wide association studies (GWAS) have identified over 800 loci associated with kidney function, yet the specific genes, variants, and pathways involved remain elusive. By integrating kidney function GWAS with human kidney expression and methylation
Xiujie Liang, Hongbo Liu, Hailong Hu, Eunji Ha, Jianfu Zhou, Amin Abedini, Andrea Sanchez-Navarro, Konstantin A. Klötzer, Katalin Susztak   +8 more
doaj   +1 more source

Expression and Analysis of Flow-regulated Ion Channels in Xenopus Oocytes

Bio-Protocol, 2017
Mechanically-gated ion channels play key roles in mechanotransduction, a process that translates physical forces into biological signals. Epithelial and endothelial cells are exposed to laminar shear stress (LSS), a tangential force exerted by flowing ...
Shujie Shi, Marcelo Carattino
doaj   +1 more source

Hypertension in Cancer Patients and Survivors

JACC. CardioOncology, 2019
Cancer patients and survivors of cancer have a greater burden of cardiovascular disease compared with the general population. Much of the elevated cardiovascular risk in these individuals is likely attributable to hypertension, because individuals with ...
Jordana B. Cohen, MD, MSCE, Abdallah S. Geara, MD, Jonathan J. Hogan, MD, Raymond R. Townsend, MD   +3 more
doaj   +1 more source

Making a Dent in Dent Disease

Function, 2020
Dent disease (DD) is a rare kidney disorder caused by mutations in the Cl−/H+ exchanger ClC-5. Extensive physiologic characterization of the transporter has begun to illuminate its role in endosomal ion homeostasis.
Katherine E Shipman, Ora A Weisz
doaj   +1 more source

Megalin Knockout Reduces SGLT2 Expression and Sensitizes to Western Diet-induced Kidney Injury

Function
Megalin (Lrp2) is a multiligand receptor that drives endocytic flux in the kidney proximal tubule (PT) and is necessary for the recovery of albumin and other filtered proteins that escape the glomerular filtration barrier.
Elynna B Youm, Katherine E Shipman, Wafaa N Albalawy, Amber M Vandevender, Ian J Sipula, Youssef Rbaibi, Allison E Marciszyn, Jared A Lashway, Emma E Brown, Corry B Bondi, Cary R Boyd-Shiwarski, Roderick J Tan, Michael J Jurczak, Ora A Weisz   +13 more
doaj   +1 more source

Feline Interstitial Cystitis Enhances Mucosa-Dependent Contractile Responses to Serotonin [PDF]

International Neurourology Journal, 2018
Purpose To determine whether responses to serotonin are altered in bladder strips from cats diagnosed with a naturally occurring form of bladder pain syndrome/interstitial cystitis termed feline interstitial cystitis (FIC). Methods Full thickness bladder
Youko Ikeda, Amanda Wolf-Johnston, James R. Roppolo, Charles A. T. Buffington, Lori Birder   +4 more
doaj   +1 more source

Superharmonic proton motion in high-energy-density organic electrodes for aqueous zinc batteries

Nature Communications
The limited proton transfer kinetics within organic positive electrodes restricts the proton storage capacity and hinders achieving high energy density in aqueous zinc-organic batteries.
Boyu Li, Jiabin Ma, Ke Yang, Yuhang Li, Maggie Ng, Yuetao Ma, Xufei An, Xing Cheng, Jinshuo Mi, Man-Chung Tang, Yan-Bing He, Feiyu Kang   +11 more
doaj   +1 more source

NRF2 in kidney physiology and disease

Physiological Reports
The role of NRF2 in kidney biology has received considerable interest over the past decade. NRF2 transcriptionally controls genes responsible for cellular protection against oxidative and electrophilic stress and has anti‐inflammatory functions.
Corry D. Bondi, Hannah L. Hartman, Roderick J. Tan   +2 more
doaj   +1 more source

Unraveling the epigenetic code: human kidney DNA methylation and chromatin dynamics in renal disease development

Nature Communications
Epigenetic changes may fill a critical gap in our understanding of kidney disease development, as they not only reflect metabolic changes but are also preserved and transmitted during cell division.
Yu Yan, Hongbo Liu, Amin Abedini, Xin Sheng, Matthew Palmer, Hongzhe Li, Katalin Susztak   +6 more
doaj   +1 more source