Results 51 to 60 of about 293,931 (317)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Ring closing reaction in diarylethene captured by femtosecond electron crystallography [PDF]

, 2013
The photoinduced ring closing reaction in diarylethene, which serves as a modelsystem for understanding reactive crossings through conical intersections, was directly observed with atomic resolution using femtosecond electron diffraction.
Liu, Lai Chung, Jean-Ruel, H., Cooney, R., Liu, L., Miller, R., Gao, Meng, Miller, R. J. Dwayne, Kochman, Michal A., Cooney, Ryan R., Morrison, C., Lu, Cheng, Jean-ruel, Hubert, Gao, M., Morrison, Carole A., Lu, C., Kochman, M.   +15 more
core   +1 more source

C library for topological study of the electronic charge density [PDF]

Journal of Computational Chemistry, 2012
AbstractThe topological study of the electronic charge density is useful to obtain information about the kinds of bonds (ionic or covalent) and the atom charges on a molecule or crystal. For this study, it is necessary to calculate, at every space point, the electronic density and its electronic density derivatives values up to second order.
David Vega, Yosslen Aray, Jesús Rodríguez   +2 more
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Electron acceptor design for 2D/2D iodinene/carbon nitride heterojunction boosting charge transfer and CO2 photoreduction

, 2022
Harvesting value-added products by CO2 reduction through photocatalysis is a sustainable approach. Against halogen-doping treatment, few-layer iodinene (FLI2) was used innovatively to construct 2D/2D van der Waals heterojunction with carbon nitride ...
Liu, Hao, Ge, Lei, Cao, Shihai, Chen, Liang, Shen, Shigang, Wang, Wenjing, Wang, Chunbo, Li, Mengxin, Zhao, Kun   +8 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Dusty space plasma diagnosis using temporal behavior of polar mesospheric summer echoes during active modification [PDF]

, 2011
The objective of this paper is to study the effect of different plasma and dust parameters on Polar Mesospheric Summer Echoes (PMSE) temporal behavior after turn-on and turn-off of radio wave heating and to use these responses to diagnose the properties ...
Senior, Andrew, A. Senior, A. Mahmoudian, Rietveld, Mike, Scales, Wayne, W. A. Scales, M. Rietveld, Mahmoudian, Alireza, Kosch, Michael, M. J. Kosch   +9 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Nonlinear Electrical Properties of One-Dimensional Nanostructures [PDF]

, 2009
A general method is first reported for reliably fabricating highly-ordered conventional superconductor nanowire arrays, with good control over nanowire cross section (down to 10 nm by 11 nm) and length (up to 200 microns).
Xu, Ke
core   +1 more source