Results 41 to 50 of about 554,215 (338)

Electron transport chain activity is a predictor and target for venetoclax sensitivity in multiple myeloma

Nature Communications, 2020
The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the 11;14 translocation, the mechanistic basis of which is unknown.
R. Bajpai, Aditi Sharma, Abhinav Achreja, C. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M Matulis, S. McBrayer, Anjali Mittal, Manali Rupji, B. Barwick, S. Lonial, A. Nooka, L. Boise, Deepak Nagrath, M. Shanmugam   +16 more
semanticscholar   +1 more source

Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I

BMC Research Notes, 2011
The transcription factor Hypoxia-Inducible Factor-1α is a master regulator of the cellular response to low oxygen concentration. Compound C, an inhibitor of AMP-activated kinase, has been reported to inhibit hypoxia dependent Hypoxia-Inducible Factor-1α ...
Hagen Thilo, Chua Yee Liu
doaj   +1 more source

24-epibrassinolide improved chilled tomato photosynthetic performance by stabilizing electron transport chain and function of photosystem II

Biologia Plantarum, 2022
To explore the protective mechanisms of brassinosteroids in the chill-induced photoinhibition in tomato (Solanum lycopersicum), we studied the effect of foliar sprayed 24-epibrassinolide (EBR, 0.1µM) on the gas exchange, chlorophyll fluorescence ...
W.-H. HU, X.-H. HU, C. LIU, B.-Q. WANG, X.-H. YAN   +4 more
doaj   +1 more source

Lactobacillus plantarum WCFS1 Electron Transport Chains [PDF]

Applied and Environmental Microbiology, 2009
ABSTRACT Lactobacillus plantarum WCFS1 requires both heme and menaquinone to induce respiration-like behavior under aerobic conditions. The addition of these compounds enhanced both biomass production, without progressive acidification, and the oxygen consumption rate. When both heme and menaquinone were present,
Brooijmans, R.J.W., de Vos, W.M., Hugenholtz, J.   +2 more
openaire   +2 more sources

Comparsion of the Effects of Succinate and NADH on Postmortem Metmyoglobin Redcutase Activity and Beef Colour Stability

Journal of Integrative Agriculture, 2014
In two experiments, the effects of succinate and NADH (reduced nicotinamide adenine dinucleotide) on metmyoglobin reductase activity and electron transport chain-linked metmyoglobin reduction were investigated and compared. In experiment 1, metmyoglobin (
Xiao-guang GAO, Zhen-yu WANG, Meng-tian TANG, Chang-wei MA, Rui-tong DAI   +4 more
doaj   +1 more source

Is impaired energy production a novel insight into the pathogenesis of pyridoxine-dependent epilepsy due to biallelic variants in ALDH7A1?

PLoS ONE, 2021
BackgroundPyridoxine-dependent epilepsy (PDE) is due to biallelic variants in ALDH7A1 (PDE-ALDH7A1). ALDH7A1 encodes α-aminoadipic semialdehyde dehydrogenase in lysine catabolism.
Anastasia Minenkova, Erwin E W Jansen, Jessie Cameron, Rob Barto, Thomas Hurd, Lauren MacNeil, Gajja S Salomons, Saadet Mercimek-Andrews   +7 more
doaj   +1 more source

A Biophysical Systems Approach to Identifying the Pathways of Acute and Chronic Doxorubicin Mitochondrial Cardiotoxicity. [PDF]

PLoS Computational Biology, 2016
The clinical use of the anthracycline doxorubicin is limited by its cardiotoxicity which is associated with mitochondrial dysfunction. Redox cycling, mitochondrial DNA damage and electron transport chain inhibition have been identified as potential ...
Bernardo L de Oliveira, Steven Niederer
doaj   +1 more source

Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain*

Journal of Biological Chemistry, 2002
We measured production of reactive oxygen species by intact mitochondria from rat skeletal muscle, heart, and liver under various experimental conditions.
J. St-Pierre, Julie A. Buckingham, Stephen J Roebuck, M. Brand   +3 more
semanticscholar   +1 more source

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Nature Neuroscience, 2019
Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2).
Steven M. Graves, Zhong Xie, Kristen A. Stout, E. Zampese, Lena F. Burbulla, Jean C. Shih, Jyothisri Kondapalli, Tommaso Patriarchi, L. Tian, L. Brichta, P. Greengard, D. Krainc, Paul T. Schumacker, D. Surmeier   +13 more
semanticscholar   +1 more source

Coordinating Electron Transport Chains to an Electron Donor

Organic Letters, 2015
Two electron transport chains (2 and 3) featuring two fullerenes with different electron acceptor strengths have been synthesized, characterized, and coordinated to a light harvesting/electron donating zinc porphyrin. Electrochemical assays corroborate the redox gradients along the designed electron transport chains, and complementary absorption and ...
Carmen Villegas, Maximilian Wolf, Damien Joly, Juan Luis Delgado, Dirk M. Guldi, Nazario Martín   +5 more
openaire   +4 more sources