Results 71 to 80 of about 554,215 (338)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Dissection of photosynthetic electron transport process in sweet sorghum under heat stress. [PDF]

PLoS ONE, 2013
Plant photosynthesis and photosystem II (PSII) are susceptible to high temperature. However, photosynthetic electron transport process under heat stress remains unclear.
Kun Yan, Peng Chen, Hongbo Shao, Chuyang Shao, Shijie Zhao, Marian Brestic   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of exogenously applied 20-hydroxyecdysone on the efficiency of primary photosynthetic processes substantially differs across plant species

Photosynthetica, 2020
The effects of 20-hydroxyecdysone on the primary photosynthetic processes (PPP) were examined across twelve plant species using the OJIP chlorophyll fluorescence analysis.
D. HOLÁ, K. FRIMLOVÁ, M. KOČOVÁ, H. MARKOVÁ, O. ROTHOVÁ, L. TŮMOVÁ   +5 more
doaj   +1 more source

Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain

Journal of Biological Chemistry, 2017
SIRT5 is a lysine desuccinylase known to regulate mitochondrial fatty acid oxidation and the urea cycle. Here, SIRT5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus.
Yuxun Zhang, Sivakama S. Bharathi, Matthew J. Rardin, Jie Lu, Katherine V Maringer, S. Sims-Lucas, E. Prochownik, B. Gibson, E. Goetzman   +8 more
semanticscholar   +1 more source

Mitochondrial oxidative phosphorylation: Debunking the concepts of electron transport chain, proton pumps, chemiosmosis and rotary ATP synthesis [PDF]

, 2017
Herein (the first part of my work), I debunk the long-standing hypotheses that explain mitochondrial oxidative phosphorylation. Simple calculations point out that mitochondria are highly proton-deficient microcosms and therefore, elaborate proton pump ...
K. Manoj
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Chlorophyll fluorescence in the evaluation of photosynthetic electron transport chain inhibitors in the pea

Revista Ciência Agronômica
The study aimed to evaluate the behavior of the chair of photosynthetic electron transport in the presence of DCMU and atrazine in detached leaves of pea through simultaneous measurements of the kinetics of fluorescence transient, fluorescence delayed ...
Marcio Espinosa Farias, Emanuela Garbin Martinazzo, Marcos Antonio Bacarin   +2 more
doaj   +1 more source

The Electron Transport Chain of Shewanella oneidensis MR-1 can Operate Bidirectionally to Enable Microbial Electrosynthesis [PDF]

, 2023
Kathryne C. Ford, Michaela A. TerAvest
openalex   +1 more source

Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1–Parkin pathway and modulate cellular drug response

Journal of Biological Chemistry, 2017
Sorafenib (Nexavar) is a broad-spectrum multikinase inhibitor that proves effective in treating advanced renal-cell carcinoma and liver cancer. Despite its well-characterized mechanism of action on several established cancer-related protein kinases ...
Conggang Zhang, Zeyu Liu, Eric N Bunker, A. Ramirez, Schuyler Lee, Yinghua Peng, A. Tan, S. Gail Eckhardt, Douglas A. Chapnick, Xuedong Liu   +9 more
semanticscholar   +1 more source