Results 161 to 170 of about 1,110,577 (301)

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Photonic Time Crystals and Time‐Varying Electromagnetic Metamatter: A New Direction for Ultrafast Tunable Photonic and Microwave Materials and Devices

Advanced Science, EarlyView.
Photonic time crystals (PTCs) are systems in which electromagnetic parameters are modulated periodically in time, producing momentum bandgaps via temporal scattering rather than spatial Bragg processes. This review examines the theoretical frameworks, modeling, and computational tools for time‐varying media, and summarizes experimental demonstrations ...
Ranjan Kumar Patel, Shriram Ramanathan, Ronald P. Jenkins, Michael J. Carter   +3 more
wiley   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Author Correction: Gate tuning of coupled electronic and structural phase transition in atomically thin Ta₂NiSe₅. [PDF]

Nat Commun
Wei K, Luo Y, Watanabe K, Taniguchi T, Guo Y, Xi X.   +5 more
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Author Correction: Wafer-scale high-κ HfO₂ dielectric films with sub-5-Å equivalent oxide thickness for 2D MoS₂ transistors. [PDF]

Nat Commun
Zhang S, Zhang T, Yu H, Li T, Li X, Cui C, Zhou Y, Guo H, Wang S, Zheng D, Huang L, Bai L, Liu S, Shen C, Yang W, Du L, Shi D, Xian L, Tao X, Chai Y, Li N, Zhang G.   +21 more
europepmc   +1 more source

Transient Terahertz Oscillations During Photoinduced Polarization Topology Reconfiguration in Ferroelectric Superlattices

Advanced Science, EarlyView.
Terahertz resonances in crystalline heterostructures could close a spectral gap between conventional electronics and photonics while opening new windows on non‐equilibrium lattice dynamics. Femtosecond optical screening of the depolarization field in epitaxial PbTiO3/SrTiO3 superlattices launches a collective polar mode that oscillates near 1 THz and ...
Deepankar Sri Gyan, Hyeon Jun Lee, Xiangwei Guo, Youngjun Ahn, Samuel D. Marks, Mohammed H. Yusuf, Matthew Dawber, James M. Glownia, Diling Zhu, Takahiro Sato, Sanghoon Song, Haidan Wen, Jia‐Mian Hu, Paul G. Evans   +13 more
wiley   +1 more source

Author Correction: Advances, challenges and prospects of origami and kirigami optoelectronics. [PDF]

Nat Commun
Lee D, Kim SB, Kim J, Yoo S.
europepmc   +1 more source

Dirac Surface‐State Driven Broad Spectral Band Low Quantum Energy Photoresponse in Quaternary Topological BiSbSe2Te

Advanced Science, EarlyView.
Quaternary topological BiSbSe2Te are synthesized and demonstrates a broad spectral band photoresponse, ranging from infrared to terahertz and to millimeter waves, with a particular excellence on detection of low quantum energy terahertz photons. The observed photoresponse is attributed to the excitation of plasmonic nonequilibrium electrons originating
Tianning Zhang, Jinchao Tong, Jiantian Zhang, Peng Yu, Heng Luo, Luo Yan, Boyu Yang, Tiantian Huang, Junhui Ran, Yan Chen, Liujiang Zhou, Xin Chen, Ning Dai, Jianlu Wang, Junhao Chu   +14 more
wiley   +1 more source