Results 41 to 50 of about 874,969 (297)
Array languages and the challenges of modern computer architecture [PDF]
, 2004 There has always been a close relationship between programming language design and computer design. Electronic computers and programming languages are both 'computers' in Turing's sense.
Blelloch G., Paul Cockshott
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins
FEBS Open Bio, EarlyView.We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó +7 more
wiley +1 more source
From Things to Services: A Social IoT Approach for Tourist Service Management
IEEE Access, 2020 In the context of Internet of Things (IoT), the cooperation and synergy between varied and disparate communicating objects is strained by trustworthiness, confidentiality and interoperability concerns.
George Alex Stelea +5 more
doaj +1 more source
Target-Oriented Investigation of Online Abusive Attacks: A Dataset and Analysis
IEEE Access, 2023 Despite a body of research revolving around online abusive language, aiming at different objectives such as detection, diffusion prediction, and mitigation, existing research has seldom looked at factors motivating this behaviour.
Raneem Alharthi +3 more
doaj +1 more source
What's New at the University of Alaska Southeast William A. Egan Library [PDF]
, 2010 Egan Library Open House; New Electronic Resources; Library Computers; Library's Faculty Resources Page; Remember to contact your library ...
core
Cultural consequences of computing technology [PDF]
, 2012 Computing technology is clearly a technical revolution, but will most probably bring about a cultural revolution\ud as well. The effects of this technology on human culture will be dramatic and far-reaching.
Memmi, Daniel
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Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Harmonic correction in power supplies feeding non-linear loads [PDF]
, 2014 This paper focuses on the design of an electronic circuit which can be used in conjunction with the power supplies used at the input of non-linear loads (computers, TV sets, etc.) in order to filter out the input current harmonics in such loads.
Darwish, M, Dimitriadis, P
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Practice Recommendations for Genetic Testing of Ataxias
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Over the past decade, significant advances in genetic testing for ataxia have improved diagnostic accuracy, informed clinical trial eligibility, guided treatment decisions, and enabled cascade testing of at‐risk relatives. While guidance exists for other neurogenetic conditions, there are no standardized guidelines on genetic ...
Sharan R. Srinivasan +7 more
wiley +1 more source