Results 61 to 70 of about 889,621 (343)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Implementation of an environmental management system in a company for computers and electronic devices repairing [PDF]

Journal of Research and Innovation for Sustainable Society, 2019
The paper presents the conditions, objectives and stages necessary to implement an ISO 14001Environmental Management System in a company for computers and electronic devices repairing.
I Radulescu1 , A V Radulescu, M M Nicolescu   +2 more
doaj   +1 more source

Target-Oriented Investigation of Online Abusive Attacks: A Dataset and Analysis

IEEE Access, 2023
Despite a body of research revolving around online abusive language, aiming at different objectives such as detection, diffusion prediction, and mitigation, existing research has seldom looked at factors motivating this behaviour.
Raneem Alharthi, Rajwa Alharthi, Ravi Shekhar, Arkaitz Zubiaga   +3 more
doaj   +1 more source

A fault-tolerant clock [PDF]

, 1973
Computers must operate correctly even though one or more of components have failed. Electronic clock has been designed to be insensitive to occurrence of faults; it is substantial advance over any known ...
Daley, W. P., Mckenna, J. F., Jr.
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Reducing Energy Consumption in Embedded Systems Applications

Technologies
One of the most important challenges in modern digital systems, especially regarding autonomous embedded systems, is energy efficiency. This work studies an energy consumption optimization approach on a microcontroller that implements IoT-like ...
Ioannis Sofianidis, Vasileios Konstantakos, Spyridon Nikolaidis   +2 more
doaj   +1 more source

Computation in electron microscopy [PDF]

Acta Crystallographica Section A Foundations and Advances, 2016
Some uses of the computer and computation in high-resolution transmission electron microscopy are reviewed. The theory of image calculation using Bloch wave and multislice methods with and without aberration correction is reviewed and some applications are discussed.
openaire   +2 more sources

Adding calcium improves lithium ferrite core [PDF]

, 1969
Adding calcium increases uniformity of grain growth over a wide range of sintering temperatures and reduces porosity within the grain. Ferrite cores containing calcium have square hysteresis loops and high curie temperatures, making them useful in ...
Lessoff, H.
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source