Results 51 to 60 of about 5,931,270 (391)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

RuO2 electronic structure and lattice strain dual engineering for enhanced acidic oxygen evolution reaction performance

Nature Communications, 2022
Developing highly active and durable electrocatalysts for acidic oxygen evolution reaction remains a great challenge due to the sluggish kinetics of the four-electron transfer reaction and severe catalyst dissolution.
Yin Qin, Tingting Yu, S. Deng, Xiao-Ye Zhou, Dongmei Lin, Qian Zhang, Zeyu Jin, Danfeng Zhang, Yan‐Bing He, H. Qiu, Lunhua He, Feiyu Kang, Kaikai Li, Tong-Yi Zhang   +13 more
semanticscholar   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

p-Band Engineering in Artificial Electronic Lattices

Physical Review X, 2019
Artificial electronic lattices, created atom by atom in a scanning tunneling microscope, have emerged as a highly tunable platform to realize and characterize the lowest-energy bands of novel lattice geometries.
M. R. Slot, S. N. Kempkes, E. J. Knol, W. M. J. van Weerdenburg, J. J. van den Broeke, D. Wegner, D. Vanmaekelbergh, A. A. Khajetoorians, C. Morais Smith, I. Swart   +9 more
doaj   +1 more source

Engineering Education Through Electronic Learning and its Essential Infrastructures in Higher Education System

آموزش مهندسی ایران, 2009
Rapid growth of information and communications technologies has removed time and space limitations in education and achieved lifelong learning. Today with growth of industries and physical distance between industries and universities it is felt that more
Tahereh Gholami
doaj   +1 more source

Berry Phase Transition in Twisted Bilayer Graphene [PDF]

, 2016
The electronic dispersion of a graphene bilayer is highly dependent on rotational mismatch between layers and can be further manipulated by electrical gating.
Haug, Rolf J., Rode, Johannes C., Schmidt, Hennrik, Smirnov, Dmitri   +3 more
core   +2 more sources

A CNN based multifaceted signal processing framework for heart rate proctoring using Millimeter wave radar ballistocardiography [PDF]

Array, 2022
Rafid Umayer Murshed, Md. Abrar Istiak, Md. Toufiqur Rahman, Z. B. Ashraf, Md. Saheed Ullah, Mohammad Saquib Department of Electrical, Electronic Engineering, Bangladesh University of Engineering, Technology, Dhaka, 1000, Bangladesh Department of Electrical, Computer Engineering, T. Dallas, Richardson, 75080, Texas, Usa   +17 more
semanticscholar   +1 more source

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source