Results 271 to 280 of about 2,528,291 (336)

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

Malaria test positivity, Plasmodium species distribution, and risk factors in Ho Municipality, Ghana: a retrospective analysis of seasonal and demographic trends (2020-2022). [PDF]

Malar J
Squire DS, Afuah GM, Dika ND, Dogbey P, Bohli JK, Logosu PE, Tanson PA, Avorkliya R, Donaldy W, Ablordey K, Kwadzokpui PK.   +10 more
europepmc   +1 more source

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

Training social care staff in promoting self-determination and nutritional health for people with intellectual disabilities using 360^o virtual reality videos and ethical reflection: a qualitative study. [PDF]

BMC Health Serv Res
Johnsen HM, Steig MH, Ersfjord EMI, Safari MC, Fone AM, Melby KL.   +5 more
europepmc   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Design and implementation of a theory of planned behavior-based nutrition education intervention for adolescent girls in rural Nepal: a school-based cluster-randomized controlled trial. [PDF]

Trials
Bhandari TR, Paudel S, Chapagain N, Thapa YO, Nagila A, Kawata R, Iwakuni A, Lee K, Hiroko S.   +8 more
europepmc   +1 more source

Can the remuneration scheme of general practitioners affect their antibiotic prescription behaviour? [PDF]

Health Econ Rev
Zykova YV, Hoff EH, Kraft KB, Mykletun A, Østby KA.   +4 more
europepmc   +1 more source

Impact of resuscitation-trained healthcare workforce availability on neonatal asphyxia mortality: a population-based study. [PDF]

Resusc Plus
Kawakami MD, Sanudo A, Marinonio ASS, Areco KN, Balda RCX, Miyoshi MH, Costa-Nobre DT, Konstantyner T, Vieira E Oliveira CN, Bandiera-Paiva P, Freitas RMV, Teixeira MLP, Waldvogel B, Kiffer CRV, de Almeida MF, Guinsburg R.   +15 more
europepmc   +1 more source

Exploring documentation and reporting practices in malaria tracking: a mixed-methods study among formal drug retail shops in Hohoe Municipal, Ghana. [PDF]

Malar J
Loglo V, Gmayinaam VU, Ampomah MA, Boateng P, Ansah EK.   +4 more
europepmc   +1 more source

Effects of intramuscular quadratus lumborum block on post-cesarean pain: a randomized controlled trial. [PDF]

Sci Rep
Zhong Y, Tang Y, Zhang J, Pan X, Li D, Huang Y, Li D.   +6 more
europepmc   +1 more source