Results 151 to 160 of about 1,533 (217)

Integrating Ecology and Economics in Agent‐Based Models to Support Agricultural Policy

Advanced Science, EarlyView.
Agent‐based models are valuable tools for studying social‐ecological systems in agriculture. This review maps how existing agent‐based models represent the human and natural domains of agriculture, and discusses developments in economic and ecological agent‐based modeling.
Daniel Vedder, Judith Josephin Rakowski, Lea‐Deborah Kolb, Greta Sophie Theilen‐Loges, Sebastian Lakner, Guy Pe'er   +5 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

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Perceptions of Electronic Navigation Displays

Behaviour and Information Technology, 2013
This study evaluated aesthetics and usability of in-vehicle electronic navigation maps. Experiment 1 examined map displays that varied in the amount of information presented, abstraction level, graphic/colour style and the existence of landmarks in both urban and rural environments using objective and subjective measures.
Tal Oron-Gilad
exaly   +2 more sources

Human Navigation in Electronic Environments

CyberPsychology & Behavior, 2001
The problem of human navigation in electronic environments is central to the debate on human experience with new technologies. The studies carried out, in particular in environmental psychology, offer a starting point for a better understanding of the origin of cognitive difficulties and the problems that can occur when moving in new habitats.
GAMBERINI, LUCIANO, BUSSOLON S.
openaire   +3 more sources

Electronic cigarettes: navigating the vapor

Annals of Allergy, Asthma & Immunology, 2014
Electronic cigarettes (e-Cigarettes) are novel nicotine delivery systems that have the potential to drastically change the landscape of nicotine addiction and tobacco use. Their increasing popularity has raised concerns that e-Cigarettes might undercut the gains associated with tobacco cessation efforts and limits on public use and advertising.1,2 ...
Andrew S, Nickels, Avni Y, Joshi, Chitra, Dinakar   +2 more
openaire   +2 more sources

Navigation in Electronic Worlds.

CHI '97 extended abstracts on Human factors in computing systems looking to the future - CHI '97, 1997
This two-day workshop will bring together researchers and designers working on different topics relevant to navigation in electronic information worlds. The central focus will be on human navigation in electronic information emphasizing fundamental issues in research and design. The chosen focus requires awareness of the broader topics of navigation in
George W. Furnas, Susanne Jul
openaire   +2 more sources

Social navigation and annotation for electronic books

Proceedings of the 2008 ACM workshop on Research advances in large digital book repositories, 2008
Modern efforts on digitizing electronic books focus on preserving authentic "spatial" representation of the original sources. The new format requires new tools to help users to access, process, and make sense of digital information. This paper presents an approach which assists users of these new "spatial" sources by giving them a combination of ...
Jae-Kyung Kim, Rosta Farzan, Peter Brusilovsky   +2 more
openaire   +2 more sources