Results 61 to 70 of about 31,215 (276)

Smoking‐Induced STC2+ Tumor Cells Drive Tumor‐Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single‐Cell Transcriptomics

Advanced Science, EarlyView.
This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen, Lianchong Gao, Qiang Huang, Liang Zhou, Chengzhi Xu, Chunping Wu   +5 more
wiley   +1 more source

Detection of nicotin in commercial samples of liquids for electronic cigarettes

Новые технологии, 2017
Sale of liquids for electronic cigarettes requires constant monitoring for this product at the market. The article presents the results of the study on the detection of nicotine in commercial samples of liquids for electronic cigarettes, obtained using ...
T. A. Perezhogina, N. A. Duruncha, I. M. Ostapchenko   +2 more
doaj  

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Increasing Awareness of Health Risks Associated with Vaping in Youths [PDF]

, 2019
E-cigarette and use of electronic nicotine delivery systems is a growing trend among youths in the United States. According to the National Institute of Health 2018 Monitoring the Future Survey, the 10th and 12th grade increases in nicotine vaping are ...
Wang, Patricia
core   +1 more source

Identification of Cytotoxic Flavor Chemicals in Top-Selling Electronic Cigarette Refill Fluids. [PDF]

, 2019
We identified the most popular electronic cigarette (EC) refill fluids using an Internet survey and local and online sales information, quantified their flavor chemicals, and evaluated cytotoxicities of the fluids and flavor chemicals.
Hua, My, Luo, Wentai, McWhirter, Kevin J, Omaiye, Esther E, Pankow, James F, Talbot, Prue   +5 more
core   +2 more sources

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

PATHOPHYSIOLOGY AND PATHOMORPHOLOGY OF THE LUNGS IN USERS OF ELECTRONIC NICOTINE DELIVERY DEVICES: CLINICAL AND EXPERIMENTAL DATA

Байкальский медицинский журнал
Relevance. Currently, the use of tobacco and tobacco products has acquired the character of a global epidemic, and the number of diseases associated with this harmful habit is steadily growing.
Evgenia V. Guzovskaia, Lyudmila O. Gutsol, Svetlana N. Serebrennikova, Igor Zh. Seminskiy, Lyudmila A. Dmitrieva   +4 more
doaj   +1 more source

The Effect of Electronic Cigarette User Modifications and E-liquid Adulteration on the Particle Size Profile of an Aerosolized Product [PDF]

, 2019
Electronic cigarettes (e-cigarettes) are an alternate nicotine delivery system that generate a condensation aerosol to be inhaled by the user. The size of the droplets formed in the aerosol can vary and contributes to drug deposition and ultimate ...
Halquist, Matthew S., Kosmider, Leon, McGee Turner, Joseph B., Mulder, Haley A., Patterson, Jesse L., Peace, Michelle R., Poklis, Alphonse, Poklis, Justin L.   +7 more
core   +1 more source

Feasibility of Electronic Nicotine Delivery Systems in Surgical Patients [PDF]

Nicotine & Tobacco Research, 2016
Cigarette smoking is a known risk factor for postoperative complications. Quitting or cutting down on cigarettes around the time of surgery may reduce these risks. This study aimed to determine the feasibility of using electronic nicotine delivery systems (ENDS) to help patients achieve this goal, regardless of their intent to attempt long-term ...
Margaret, Nolan, Scott, Leischow, Ivana, Croghan, Sandeep, Kadimpati, Andrew, Hanson, Darrell, Schroeder, David O, Warner   +6 more
openaire   +2 more sources