Results 61 to 70 of about 18,321,701 (185)

Ethical issues raised by a ban on on the sale of electronic nicotine devices [PDF]

, 2015
BackgroundSome countries have banned the sale of electronic nicotine delivery systems (ENDS)
Hall, Wayne, Gartner, Coral, Forlini, Cynthia   +2 more
core   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Abuse Liability Assessment of the RELX Infinity® Electronic Nicotine Delivery System Among Adult Smokers and Electronic Nicotine Delivery System Users

Contributions to Tobacco and Nicotine Research
Nicotine pharmacokinetics and subjective effects are important factors in assessing the abuse liability of tobacco products such as electronic nicotine delivery systems (ENDS). In addition, an abuse liability determination is informative in assessing the
Graff Donald W., Fearon Ian M., McClean Mark, Melara Rebeca, Vemuri Ramadevi, Mills Catherine   +5 more
doaj   +1 more source

The youth e-cigarette epidemic: New estimates of JUUL Labs’ revenue from youth users in the US

Tobacco Induced Diseases, 2021
Introduction Past 30-day e-cigarette use increased by 78% among high school students from 2017 to 2018, an increase attributable to pod-style devices. JUUL Labs (JUUL) insists they do not market their product to teenagers. We created several scenarios to
Bekir Kaplan, Rajeev Cherukupalli, Kevin Welding, Ryan D. Kennedy, Joanna E. Cohen   +4 more
doaj   +1 more source

Blocking Honeybee Preference for Neonicotinoids by Interfering With Dopamine Signaling

Advanced Science, EarlyView.
Honeybees (Apis mellifera) paradoxically prefer nectar containing the harmful neonicotinoid thiamethoxam. This preference is associated with transient brain dopamine elevation during proboscis extension reflex (PER) responses and active feeding, and is reduced by the dopamine receptor antagonist fluphenazine.
Jing Li, Yuan Ge, Wangjiang Feng, David C. Lyon, Pingli Dai, Yong‐Jun Liu   +5 more
wiley   +1 more source

Adolescents’ attitudes towards e-cigarette in Tunisia

European Psychiatry, 2021
Introduction E-cigarette use has increased over the last years. Many studies have examined teenagers’ attitudes towards smoking, but did not examine adolescents’ attitudes towards e-cigarettes.
R. Maalej, Y. Zgueb, A. Aissa, U. Ouali, F. Nacef   +4 more
doaj   +1 more source

Early‐Life Polyethylene Microplastic Exposure Exacerbates ADHD‐Like Behaviors in Mice via PI3K/AKT1/Nrf2 Signaling: Evidence From the Pilot Cohort and Multi‐Omics Analyses

Advanced Science, EarlyView.
Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo, Ruijin Xie, Hua Xu, Xue Xiao, Wei Xiao, Qiyang Pan, Shengjie Xu, Li Liu, Zeliang Xiao, Yue Zhou, Chenyu Sun, Yu Wu, Yueying Liu   +12 more
wiley   +1 more source

Electronic nicotine delivery systems : key facts [PDF]

This document outlines key facts related to electronic nicotine delivery systems (ENDS), including e-cigarettes.ends-key-facts-oct-2016 ...

core   +2 more sources

Clinical pharmacology of nicotine in electronic nicotine delivery systems [PDF]

, 2019
Electronic nicotine delivery systems (ENDS) are a heterogeneous class of products in which an electrically powered coil is used to heat a liquid matrix, or e-liquid, that contains nicotine, solvents (e.g.
Peruga, Armando
core   +1 more source