Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
A concept of a power electronic converter for a BLDC motor drive system in aviation
Realisation of a high-speed drive using a BLDC motor, especially that of low and medium power and with rotational speed of up to 40 000 rpm designed for use in aviation appliances, became possible due to rapid progress in electronic power control ...
Dariusz Sobczynski
doaj +1 more source
Design of Fault-Tolerant Automotive Gateway Architecture Using MC9S12XDP512 Microcontroller Device
The increasing number of electrical components and sensors in modern vehicles makes network design more challenging. The development of automotive electronics through multiple communication protocols brings out the importance of a hybrid network that is ...
Ramesh Krishnamoorthy +2 more
doaj +1 more source
FPGA implementation of online finite-set model based predictive control for power electronics [PDF]
Recently there has been an increase in the use of model based predictive control (MBPC) for power-electronic converters. MBPC allows fast and accurate control of multiple controlled variables for hybrid systems such as a power electronic converter and ...
Jacxsens, Michiel +3 more
core +2 more sources
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Electronic Speed Controller Design for a Quadcopter
Abstract Mobility was, and it is one of the most important topics in our life. The main device that it is used for mobility is the motor, and nowadays more and more importance is granted to electric motors. For controlling such an electric motor, we need an Electronic Speed Controller (ESC).
Andrei Grosu +2 more
openaire +1 more source
Attosecond screening dynamics mediated by electron-localization
Transition metals with their densely confined and strongly coupled valence electrons are key constituents of many materials with unconventional properties, such as high-Tc superconductors, Mott insulators and transition-metal dichalcogenides.
Gallmann, L. +8 more
core +1 more source
Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin +2 more
wiley +1 more source
Asymmetric Cherenkov acoustic reverse in topological insulators
A general phenomenon of the Cherenkov radiation known in optics or acoustics of conventional materials is a formation of a forward cone of, respectively, photons or phonons emitted by a particle accelerated above the speed of light or sound in those ...
Smirnov, Sergey
core +1 more source
Changes in Immune‐Inflammation Status and Acute Ischemic Stroke Prognosis in Prospective Cohort
ABSTRACT Background Inflammation is a critical risk factor for poor outcomes in cerebral infarction. Prior studies focused primarily on baseline inflammation status, neglecting dynamic longitudinal changes. We try to investigate the association between immune‐inflammation status alterations and stroke prognosis, and evaluated three systemic biomarkers'
Songfang Chen +11 more
wiley +1 more source

