Results 91 to 100 of about 286,462 (314)

Normalising a Digital Transformation

, 2021
Digital transformation research and practice has received significant attention across the information systems (IS) field in recent years. However, this area of research is still in its infancy and in particular most studies focus on the initial adoption
Carroll, Noel, Donnellan, Brian, Mc Lafferty, Brian, Conboy, Kieran   +3 more
core  

Use of a Molecular Signature Response Classifier to Inform Treatment Selection Improves Clinical Disease Activity Among Patients with Rheumatoid Arthritis Initiating a Biologic or Targeted Synthetic Disease‐Modifying Antirheumatic Drug

Arthritis Care &Research, EarlyView.
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie, Timothy Beukelman, Nicholas P. McCormick, Jeffrey R. Curtis   +3 more
wiley   +1 more source

Frequent fecal microbiota transplantation improves cognitive impairment and pathological changes in Alzheimer's disease FAD4T mice via the microbiota-gut-brain axis

Heliyon
Background: Alzheimer's disease (AD), the most prevalent form of dementia, currently lacks effective treatments or a cure. A large number of recent studies demonstrated that gut microbiota homeostasis plays a vital role in AD.
Zhiyan Zou, Dan Lei, Yuan Yin, Ruiling Xu, Huiwen Luo, Tingting Chen, Mingxue Liu, Xiaoan Li   +7 more
doaj   +1 more source

Readiness for Business Transformation

, 2020
Digital transformation has essential differences from IT software development projects because of its nature of technology-driven organizational transformation.
Li, Julia
core  

Negotiated Grammar Transformation [PDF]

, 2012
In this paper, we study controlled adaptability of metamodel transformations. We consider one of the most rigid metamodel transformation formalisms -- automated grammar transformation with operator suites, where a transformation script is built in such a
Zaytsev, V. (Vadim), Zaytsev, Vadim, Vadim Zaytsev   +2 more
core   +1 more source

Digital Transformation: The Age of Innovations in Business and Society

, 2022
This chapter considers main factors of digital transformation in business and society. The latest studies of digital ad spend in Europe and a number of marketing technology solutions all over the world within the period 2011–2020 have confirmed a rapid ...
Iryna Kovshova, Kovshova, Iryna
core   +1 more source

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

RGD hydrogel-loaded ADSC extracellular vesicles mitigate uranium-induced renal injury via TLR4/NF-κB pathway inhibition

Journal of Nanobiotechnology
Background Uranium-induced kidney damage represents a major health concern due to its toxic effects, including mitochondrial dysfunction and inflammation.
Xi Chen, Chun-Mei Dai, Bin Zhang, Wan-Xin Zhang, Zheng-Hong Huang, Jiu-Yi Jiang, Shi-Qi Hu, Jia-Hua Ma, Jia-Fu Feng   +8 more
doaj   +1 more source

Does Digital Transformation of the Australian Healthcare supply chain improve clinical safety?

, 2021
Digital transformation of the healthcare supply chain has the potential to improve clinical safety. The Covid-19 pandemic has exposed healthcare supply chain deficiencies through shortages of Personal Protective Equipment and vaccines.
Shrestha, Anup, Smith, Sean, Lane, Michael, Toleman, Mark   +3 more
core