Results 181 to 190 of about 25,210 (268)

Engineered Probiotic‐Powered Micro‐Rod Robot Bomb for Thrombus‐Penetrating Explosion

Advanced Science, EarlyView.
For thrombotic diseases with narrow therapeutic windows and persistent vascular damage; existing thrombolytic drugs are difficult to achieve precise; timely; and sustained thrombolytic effects. Here an engineered probiotic driven micro‐rod robot for targeted and penetrative treatment for thrombus is developed.
Riyue Liu, Jiale Chen, Yuanyuan Li, Nawsherwan, Cuilian Dai, Yan Wang, Jinrong Zheng, Kecheng Zhou, Mangmang Sang   +8 more
wiley   +1 more source

Emergence and transmission of Carbapenem-resistant <i>Enterobacteriaceae bla</i> _NDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery. [PDF]

Front Vet Sci
Dai YY, Wei WF, Li XZ, Yuan CY, Zhao LJ, Huang YQ, Hao M, Deng Y, Teng YJ, Yi XL.   +9 more
europepmc   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan, Jie Mei, Yun Cai, Ji Zhou, Ningyi Xue, Ying Jiang, Yan Zhang, Jingjing Huang, Yichao Zhu   +8 more
wiley   +1 more source

Adipose Tissue-Derived Exosome Maintains Metabolic Balance of Extracellular Matrix in Rat Nucleus Pulposus Cells. [PDF]

Int J Nanomedicine
Zhao R, Ma L, Li J, Liu S, Yang D, Liu G, Yang S.   +6 more
europepmc   +1 more source

Harnessing the Immunomodulation of UV‐Exposed Keratinocyte Extracellular Vesicles for Inflammatory Disorder Treatment

Advanced Science, EarlyView.
Adopting a paradigm shift that transforms a known health hazard as a potential therapeutic asset, a novel therapeutic strategy is set out to investigate for inflammatory conditions by leveraging immunosuppressive properties of UV‐irradiated keratinocytes.
Lu Liu, Ding Yang, Jingsen Ji, Gengyou Li, Haoting Chen, Yuying Yao, Chenxing Fu, Fangling Liao, Jinzhao Liu, Yaming Zhang, Zechuan Li, Jing Zhang, Huike Ma, Jingxia Zhao, Ying‐Shi Sun, Weisheng Guo, Weiping Wang   +16 more
wiley   +1 more source

Study of Class 1, 2, and 3 Integrons, Antibiotic Resistance Patterns, and Biofilm Formation in Clinical <i>Staphylococcus aureus</i> Isolates from Hospital-Acquired Infections. [PDF]

Pathogens
Hegazy EE, ElNaghy WS, Shalaby MM, Shoeib SM, Abdeen NSM, Fouda MH, Elshora OA, Elnaggar MH, Elrefaey W, Hagag RY, Elhadidy AA, Elsebaey MA, Eltomey MA, El Nakib AM, Ageez MN, Elnady MS.   +15 more
europepmc   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Assessment of the Diagnostic Accuracy of the Modified Hodge Test and Modified Carbapenem Inactivation Method for Identifying Carbapenem Resistance Mechanisms in Klebsiella pneumoniae: A Whole Genome Sequencing-Based Exploratory Study. [PDF]

Cureus
Chakraborty D, Bhatia M, Gupta P, Nagaraj G, Shamanna V, Srinitha P, Ashwini KV, Ravikumar KL.   +7 more
europepmc   +1 more source

Oral Engineered Extracellular Vesicles Based on Ion Exchange Strategy for Multipronged Management of Wilson's Disease Complicated with Reproductive Dysfunction Therapy

Advanced Science, EarlyView.
This study reports for the first time an oral targeted nanomedicine that conducts ion exchange through engineered Ganoderma‐derived extracellular vesicle, managing both the in‐copper and ex‐copper in a multi‐pronged approach, offering a promising therapeutic strategy for addressing WD with reproductive dysfunction.
Tingting Wang, Wengui Lu, Zhifei Cheng, Luyao Wang, Zhenzhen Jiang, Yike Yue, Pengyu Jiang, Zehua Xia, Lei He, Fengying Wang, Limin Wu, Qi Wang, Hui Han   +12 more
wiley   +1 more source

Cuttlefish ink nanoparticle-engineered hydrogel microspheres synergistically attenuate disc degeneration via antioxidant defense and matrix synthesis activation. [PDF]

Mater Today Bio
Jin C, Chen J, Miao Y, Tian X, Wang J, He F, Liu Y, Xu Y.   +7 more
europepmc   +1 more source