Results 191 to 200 of about 25,210 (268)

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

Sequentially assembled co-delivery nanoplatform of SIRT1 protein and SOX9-expressing plasmid for multipronged therapy of intervertebral disc degeneration. [PDF]

J Nanobiotechnology
Zhang X, Guo Q, Fang J, Cheng Q, Zhu Z, Yu Q, Wang H, Hong Y, Liu C, Yang H, Zhu C, Li B, Ni L.   +12 more
europepmc   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Co-resistance and plasmid-mediated co-dissemination of florfenicol and azithromycin resistance in non-O157 Shiga toxin-producing Escherichia coli from cattle in Xinjiang, China. [PDF]

BMC Microbiol
Wang L, Lan X, Bai Y, Huang Y, Jin W, Zhang M, Zheng X, Zhang Y, Du X, Liu Y, Ma X, Geng M, Su Z, Xie J, Tong P.   +14 more
europepmc   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source

Investigating the regulation of the miR-199a-3p/TGF-β/Smad signaling pathway by BSHXF drug-containing serum combined with ADSCs for delaying intervertebral disc degeneration. [PDF]

Front Pharmacol
Liu E, Sun Y, Yang L, Jiang H, Sun F, Chen L, Duan J, Yang S.   +7 more
europepmc   +1 more source

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

The Drosophila histone variant H2Av facilitates Notch signaling activity in a two-tier regulatory fashion. [PDF]

Cell Commun Signal
Chen Y, Zhang X, Song Y, Shen J, Zhang J.   +4 more
europepmc   +1 more source

Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage

Advanced Science, EarlyView.
Li exposure up‐regulates FOXO1 expression levels and thus promotes FOXO1‐mediated STEAP4 transcription, up‐regulating STEAP4 levels. Subsequently, STEAP4 up‐regulates intracellular Cu+ ion levels and causes cuproptosis, which further induces miscarriage.
Shuaishuai Xing, Yanbing Lin, Yi Sun, Xiaoping Yue, Qigang Fan, Jisheng Nie, Zhihong Zhang, Yajing Liu, Juntang Yang, Qingzheng Kang, Yanxin Wang, Haijun Yan, Chan Tian, Ying Chang, Huidong Zhang   +14 more
wiley   +1 more source