Results 191 to 200 of about 698,895 (334)

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

Advanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
wiley   +1 more source

RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration. [PDF]

Arthritis Res Ther
Chen W, Li D, Chen L, Fei J, Bian M, Zeng Q, Jiang Z, Wu J.   +7 more
europepmc   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Spinal amyloid deposits are common among older patients undergoing spinal stenosis decompression surgery. [PDF]

J Gen Fam Med
Madhani A, Kotturu N, Fine D, Alreshq R, Saade A, Tannoury T, Tannoury C, Ruberg FL.   +7 more
europepmc   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Blockade of IgG Fc receptors reduces pain after intervertebral disc injury. [PDF]

Pharmacol Rep
Shi X, Sahbaie P, Guo TZ, Hsu YM, Kingery WS, Clark JD.   +5 more
europepmc   +1 more source

An Anisotropic Gold‐Palladium Heterostructured Nanosystem for Synergistically Overcoming Radioresistance and Enhancing Melanoma Radioimmunotherapy

Advanced Science, EarlyView.
A multifunctional anisotropic Au‐Pd heterostructured nanosystem is developed that incorporates a plasmonically enhanced Au‐Pd core, with a shell composed of a biodegradable, Mn‐doped targeting peptide. The nanosystem integrates photothermal, radiotherapeutic, and immunomodulatory functions.
Cheng Chen, Yuqi Huang, Wandong Wang, Minghao Chao, Weiguo Sun, Yinghui Kong, Guan Jiang, Yong Gao, Fenglei Gao   +8 more
wiley   +1 more source

Emergence and transmission of Carbapenem-resistant <i>Enterobacteriaceae bla</i> _NDM-5 gene in healthy pigs in Baise, Guangxi, China: a discovery. [PDF]

Front Vet Sci
Dai YY, Wei WF, Li XZ, Yuan CY, Zhao LJ, Huang YQ, Hao M, Deng Y, Teng YJ, Yi XL.   +9 more
europepmc   +1 more source

Auxin‐Producing Pseudomonas Recruited by Root Flavonoids Increases Rice Rhizosheath Formation through the Bacterial Histidine Kinase Under Soil Drying

Advanced Science, EarlyView.
Drought is a major cause of crop losses across agricultural regions. Rhizosheath formation enhances plant resistance to drought. Polyploids may tolerate stress more effectively through increased interactions with bacteria. However, the contributions of tetraploid rice associated microbiota to rhizosheath formation under soil drying remain unclear ...
Feiyun Xu, Yongsen Wang, Jinyong Yang, Xue Zhang, Ke Wang, Fan Ding, Jiayin Pang, Lu Tong, Chuqi Bai, Shu Chen, Leyun Sun, Chongxuan Du, Ju Fang, Mengqiang Xu, Liang Li, Xin Yu, Jiahong Gengli, Jianping Liu, Qian Zhang, Zhengrui Wang, Yiyong Zhu, Huanyuan Zhang‐Zheng, Jianhua Zhang, Weifeng Xu   +23 more
wiley   +1 more source

A function of Spalt proteins in heterochromatin organization and maintenance of genomic DNA integrity.

Development
Ostalé CM, Azpiazu N, Peropadre A, Martín M, Ruiz-Losada M, López-Varea A, Viales RR, Girardot C, Furlong EEM, de Celis JF.   +9 more
europepmc   +1 more source