Advanced Science, EarlyView.Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu +11 more
wiley +1 more source
Mitofusin 1 in mitochondrial quality control and anti-inflammatory responses in nucleus pulposus cells during disc degeneration. [PDF]
Sci RepShin JW +7 more
europepmc +1 more source
Glycoprotein Proteinase in Agkistrodon bilineatus Venom [PDF]
, 1980 Johnson, Bob D. +2 more
core +2 more sources
Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits
Advanced Science, EarlyView.Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu +16 more
wiley +1 more source
Gentisic acid ameliorates lumbar disc herniation by regulating M1/M2 Polarization via the MAPK14/S100A9/Rac1/2 pathway. [PDF]
Cell Biol ToxicolLi S, Chen T, Shen X, Su W, Li X.
europepmc +1 more source
A new Principle of Thyroxine (T4) and Triiodo-thyronin (T3) Radioimmunoassay in unextracted Serum using Antisera with binding Optima at extreme pH ranges [PDF]
, 1980 Gärtner, Roland +3 more
core
Advanced Science, EarlyView.In this work, we showcased two significant scientific advances in (i) developing a portable biosensor technology for rapid decentralized prostate cancer urinary biomarker testing and reporting, with superior performance to current clinical testing practice; and (ii) proposing a clinical validation framework (for our biosensor development) which can be ...
Kevin M. Koo +14 more
wiley +1 more source
Antimicrobial Efficacy of Garlic (Allium sativum) Extract Against Aeromonas Hydrophila Isolated From Diseased Pangasius Catfish. [PDF]
Vet Med SciSiddique S, Hossain MM, Haider MN.
europepmc +1 more source
Advanced Science, EarlyView.Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang +16 more
wiley +1 more source
Do We Need to Worry About Staphylococcus epidermidis ST0409KOC, a Cheese-Isolated Strain With Bacteriocinogenic Properties? [PDF]
Mol Nutr Food ResCarneiro KO, Lima JMS, Todorov SD.
europepmc +1 more source