Results 251 to 260 of about 698,895 (334)

Unravelling lumbar disc herniation severity beyond MRI : integrated transcriptomic and metabolomic analyses highlight glycerophospholipid metabolism and inform a machine-learning diagnostic model: a pilot study. [PDF]

Bone Joint Res
Deng Q, Ren S, Zhang N, Li G, Yu Z, Li X, Cui H, Zhang Y, Zhang Y, Chen J.   +9 more
europepmc   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Mitochondrial DNA variation and intervertebral disc degeneration: a genotypic analysis in a South African cohort. [PDF]

Mol Biol Rep
Collins M, Pearce B.
europepmc   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Extended-spectrum beta-lactamases: definition, history, an update on their genetic environment and detection methods. [PDF]

J Med Microbiol
Yassara S, Zeouk I, Jaouhar S, Sbiti M, Bekhti K.   +4 more
europepmc   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Macular retinoschisis in a patient with multiple lymphoproliferative malignancies. [PDF]

Am J Ophthalmol Case Rep
Cheng J, Yang P, Chen AI, Williams T, Flaxel C.   +4 more
europepmc   +1 more source

Properties and N-Terminal amino acid sequences of three Erythrina lectins from Costa Rica (Leguminosae) [PDF]

, 1994
Aragón-Ortiz, Federico, Fink, Edwin, Nanne-Echandi, Clara I.   +2 more
core  

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

MOTS-c-modified functional self-assembly peptide hydrogels enhance the activity of nucleus pulposus-derived mesenchymal stem cells of intervertebral disc degeneration. [PDF]

Mater Today Bio
Lin Y, Yang RY, Li J, Shao SZ, Shi XQ, Huang ZW, Zhang SH, Liu FJ, Zhang YS, Zhang SQ, Zhang SM, Wen TY, Tao H.   +12 more
europepmc   +1 more source