Results 191 to 200 of about 158,457 (326)

Electrophysiologic mechanisms responsible for inotropic responses to ketamine in guinea pig and rat myocardium.

open access: yesAnesthesiology, 1992
M. Endou   +4 more
semanticscholar   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite   +9 more
wiley   +1 more source

Structural determinants of re‐entrant drivers in atrial fibrillation: insights from digital twins derived from 3D micrometre‐resolution imaging of human heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Digital heart models of human donor atria with cardiac co‐morbidities revealed that regions with AWT variation, aligned myofibres adjacent to disorganised zones and fibrotic borders promoted the localisation and stability of RDs. AWT had a global influence, whereas fibre orientation and fibrosis exerted chamber‐specific regional ...
Anuradha Kulathilaka   +8 more
wiley   +1 more source

Long term outcome of cavotricuspid isthmus cryoablation for the treatment of common atrial flutter in 180 patients: A single center experience [PDF]

open access: yes, 2008
Wendel Moreira   +46 more
core   +1 more source

Design and characterization of the first peptidomimetic molecule that prevents acidification-induced closure of cardiac gap junctions.

open access: yesHeart Rhythm, 2010
Vandana Verma   +6 more
semanticscholar   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier   +3 more
wiley   +1 more source

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