Results 141 to 150 of about 209,623 (240)

Astrocyte‐Associated ABCA1/APOE Responses Accompany Hippocampal Lipid Remodeling and Ectopic Neuronal Accumulation During Epileptogenesis

Advanced Science, EarlyView.
During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen, Xiao‐Rui Shi, Jia‐Yi Chen, Ying‐Ting Wang, Le Du, Yang Ni, Jun‐Min Chen, An‐Chen Guo, Qian Wu, Jian‐Ping Wu, Qun Wang   +10 more
wiley   +1 more source

Chemical standardization of kava (<i>Piper methysticum</i>) extract using UHPLC-MS/MS and the method of standard addition. [PDF]

Pharm Biol
Muchiri RN, Thun NR, van Breemen RB.
europepmc   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Sensitivity Enhancement by Dual Deflection Electrodes in an Electrospray Ionization Source. [PDF]

Rapid Commun Mass Spectrom
Date M, Kumano S, Sugiyama M, Hasegawa H, Watanabe M.   +4 more
europepmc   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Gold Clusters With Open‐Shell Ligands: Superatom Mediated Magnetic Interaction

Angewandte Chemie, EarlyView.
Open‐shell verdazyl radicals were covalently integrated with atomically precise Ir‐doped Au12 (Ir@Au12) superatoms. The resulting radical–superatom hybrids exhibit photoinduced electron transfer, spin delocalization onto the metal‐cluster core, and weak ferromagnetic communication between radicals mediated by the superatomic electronic structure ...
Katsuya Mutoh, Kosei Hayashi, Yoichi Kobayashi, Kazunobu Sato, Rika Tanaka, Daichi Kitagawa, Tatsuya Tsukuda, Takuya Nakashima   +7 more
wiley   +2 more sources

Comprehensive metabolomic profiling of Angiostrongylus cantonensis across its life cycle reveals developmental and host-associated metabolic signatures. [PDF]

Infect Dis Poverty
Hu Y, Yu B, Zhan R, Zhang T, Zhang Y, Zhou Y, Wei H, Lv Z.   +7 more
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

Proton‐Induced Perthionitrite‐Mediated Zinc Thiolate Persulfidation

Angewandte Chemie, EarlyView.
A thiolate‐supported zinc thionitrite complex reacts with S8 to insert sulfur at both Zn–S bonds. Although SNO− persulfidation to SSNO− is facile, thiolate persulfidation is less favored in comparison. These thermodynamic differences between S–S‐containing moieties are also observed for free perthiolate and SSNO− anions.
Madeline N. Riffel, Oluwafemi O. Ishola, Allen G. Oliver, Emily Y. Tsui   +3 more
wiley   +2 more sources