Results 41 to 50 of about 209,623 (240)

Electrospray-assisted encapsulation of caffeine in alginate microhydrogels

, 2018
One of the major challenges with microencapsulation and delivery of low molecular weight bioactive compoundsis their diffusional loss during storage and process conditions as well as under gastric conditions. In an attempt toslow down the release rate of
Nick Tucker (17168905), Rassoul Kadkhodaee (17194657), Behrouz Ghorani (17193958), Alireza Mehregan Nikoo (17223589), Hussam Razzaq (17194645)   +4 more
core   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Continuous Near-Field Electrospraying Using a Glass Capillary Nozzle

Micromachines, 2018
A continuous near-field electrospray process has been developed to deposit micropatterns. Different from traditional electrospray technologies, the nozzle-to-substrate distance was shortened to less than 5 mm, and a glass capillary nozzle with a diameter
Xiang Wang, Jinghua Lin, Jiaxin Jiang, Shumin Guo, Wenwang Li, Gaofeng Zheng   +5 more
doaj   +1 more source

Relative affinity constants by electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry: calmodulin binding to peptide analogs of myosin light chain kinase [PDF]

, 2003
Synthetic RS20 peptide and a set of its point-mutated peptide analogs have been used to analyze the interactions between calmodulin (CaM) and the CaM-binding sequence of smooth-muscle myosin light chain kinase both in the presence and the absence of Ca2+.
Lafitte, Daniel, Vainiotalo, Pirjo, Nousiainen, Marjaana, Derrick, Peter J.   +3 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A new electrospray method for targeted gene delivery. [PDF]

, 2018
A challenge for gene therapy is absence of safe and efficient local delivery of therapeutic genetic material. An efficient and reproducible physical method of electrospray for localized and targeted gene delivery is presented.
David Hradetzky, Paulius Ruzgys, Tamò, Luca, Ruzgys, Paulius, Thomas Geiser, Geiser, Thomas, Gazdhar, Amiq, Šatkauskas, Saulius, Saulius Šatkauskas, Amiq Gazdhar, Boehringer, Stephan, Tamò, Luca Giuseppe Athos, Hradetzky, David, Stephan Boehringer, Luca Tamò, Boehringer S, Gazdhar A, Hradetzky D, Šatkauskas S, Geiser T, Ruzgys P, Tamò L   +21 more
core   +2 more sources

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Preliminar sizing of an electrospray thruster [PDF]

, 2022
As there isn’t a precise model of electrospray thrusters what I will try to do in this master thesis is to find a mathematical model that describes them in a simple way. After exposing some physical concepts I will study the physics of conductive liquids
Rostello, Marco
core  

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source