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Electrospray Ionization Using Wooden Tips
Analytical Chemistry, 2011Electrospray ionization (ESI) is a mass spectrometric technique widely used in various fields including chemistry, biology, medicine, pharmaceutical industry, clinical assessment, and forensic science. In this study, we report a simple and economical ESI-mass spectrometry (MS) technique, which makes use of disposable wooden tips (wooden toothpicks) for
Bin Hu +3 more
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Desorption electrospray ionization of aerosol particles
Rapid Communications in Mass Spectrometry, 2007AbstractWe have applied desorption electrospray ionization to aerosol particles. Ions were formed from aerosols by merging suspended dry particles with an electrospray of solvent in a modified ion trap mass spectrometer. Dry aerosol particles were generated using a fluidized bed powder disperser and directed toward the inlet of the mass spectrometer. A
Yohannes H. Rezenom +2 more
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Integration of electropreconcentration and electrospray ionization in a microchip
Journal of Chromatography A, 2018A microfluidic glass chip for performing sensitive mass spectrometry (MS) is developed by integrating nanochannel-based electropreconcentration with electrospray ionization (ESI). Cation analytes in acidic buffer conditions (∼pH 3) were preconcentrated at a micro-nano-microchannel junction where a positively charged polymer, polyE-323, is coated to ...
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Mechanistic aspects of electrospray ionization
Journal of Chromatography A, 1998Abstract Electrospray ionization (ESI) mass spectrometry can be divided into three steps: Nebulization of a sample solution into electrically charged droplets, liberation of ions from droplets, and transportation of ions from the atmospheric pressure ionization source region into the vacuum and mass analyzer of the mass spectrometer.
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Microfabrication of polydimethylsiloxane electrospray ionization emitters
Journal of Chromatography A, 2001Microfabricated polydimethylsiloxane (PDMS) emitters for electrospray ionization mass spectrometry (ESI-MS) were implemented as tips along the edge of the PDMS device by three methods which utilize soft lithography processes. These microfabrication methods for producing PDMS emitters as an integral part of a microfluidic device will facilitate ...
Daniel R. Knapp, Jin-Sung Kim
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Electrospray Ionization Mass Spectrometry of Oligonucleotides
Current Protocols in Nucleic Acid Chemistry, 2008AbstractBecause of the high molecular weights and thermal lability of biomolecules such as nucleic acids and protein, they can be difficult to analyze by mass spectrometry. Such analyses require a “soft” ionization method that is capable of generating intact molecular ions.
Colette M. Castleberry +2 more
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Electrospray Ionization: Theory and Application
1997A great deal of chemistry and most of biochemistry concerns reactions taking place in solution. The development and application of an introduction and ionization technique which allows direct sampling from solution has therefore been a prominent objective of analytical mass spectrometry for many years.
Scott G. Summerfield +3 more
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Electrospray ionization source with a rear extractor
Journal of Mass Spectrometry, 2018AbstractA new electrospray source design is introduced by having an extractor electrode placed at 1 to 2 mm behind the emitter tip. The extractor was integrated into the sprayer body as a single device. An insulating tube was used to isolate the emitter from the extractor and to deliver the sheath gas for the electrospray.
Lee Chuin Chen +4 more
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Oxidation of peptides during electrospray ionization
Rapid Communications in Mass Spectrometry, 1993Abstract[M+H+16]+ ions were observed in the electrospray ionization mass spectra of several synthetic and maturally occurring peptides. Initial results have shown that the appearance of the modification is dependent on the field strength at the electrospray needle and the flow rate of the solution passing through the capillary.
Gert Talbo +2 more
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An Electrospray Ionization Source for Integration with Microfluidics
Analytical Chemistry, 2002We have demonstrated a new electrospray ionization (ESI) device incorporating a tip made from a shaped thin film, bonded to a microfluidic channel, and interfaced to a time-of-flight mass spectrometer (TOFMS). A triangular-shaped thin polymer tip was formed by lithography and etching.
David A. Czaplewski +5 more
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