Results 251 to 260 of about 203,215 (351)

Flavonoid Profile, Biological Potentials, and In Silico Approaches of Methanol Extracts on AChE: Amaranthus retroflexus L.

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study investigated the flavonoid compounds and their biological activities in methanol extracts obtained from root, stem, leaf, and flower parts of Amaranthus retroflexus L. Flavonoids in the extracts were characterized for the first time by liquid chromatography–highresolution mass spectrometry (LC–HRMS), and a total of eight flavonoid ...
Bedrettin Selvi, Güler Durmuş, Mustafa Ceylan, Şuheda Yıldırım, Ümit M. Koçyiğit, Ümit Yırtıcı, Volkan Eyüpoğlu   +6 more
wiley   +1 more source

Desorption Electrospray Ionization Mass Spectrometry Imaging Techniques Depict a Reprogramming of Energy and Purine Metabolism in the Core Brain Regions of Chronic Social Defeat Stress Mice. [PDF]

Metabolites
Song Y, Xiao F, Aa J, Wang G.
europepmc   +1 more source

Antitumor and Cytogenotoxic Activities of Libidibia ferrea Hydroalcoholic Extracts in Murine Breast Carcinoma

Chemistry &Biodiversity, EarlyView.
ABSTRACT Breast cancer is the most prevalent cancer type among women worldwide, and there is a critical need for more effective and safer treatments, especially for aggressive and therapy‐resistant subtypes. Libidibia ferrea, a native plant from Brazil, exhibits anti‐inflammatory, antimicrobial, antioxidant, and antitumor properties.
Diego Pereira de Menezes, Evaldo dos Santos Monção Filho, Atanara Alves de Sousa, João Pedro Alves Damasceno do Lago, Karla Darlianny Mourão Cavalcante, Fernanda Alves de Sousa Cavalcante, Irismara Sousa Silva, Marina Pinto Sanches, Semiramis Jamil Hadad do Monte, Ester Miranda Pereira, Paulo Michel Pinheiro Ferreira, Joao Marcelo de Castro e Sousa, Gerardo Magela Vieira Júnior, Dalton Dittz   +13 more
wiley   +1 more source

Cytotoxic Activity of Opopanax hispidus (Friv.) Griseb.: Characterization of a New Chalcone‐type Compound

Chemistry &Biodiversity, EarlyView.
ABSTRACT The present study aimed to investigate cytotoxic compounds of Opopanax hispidus (Friv.) Griseb. through in vitro, in silico, and phytochemical analyses. The cytotoxic activity of O. hispidus was evaluated against four different cancer cell lines – lung (A549), breast (MCF‐7), liver (HepG2), and cervix (HeLa) – as well as one healthy cell line (
Kevser Taban, İpek Süntar, Perihan Gürbüz, Esra Emerce, Osman Tugay, Şengül Dilem Doğan, Beyza Hamur, Ahmet Ceyhan Gören   +7 more
wiley   +1 more source

Rotenoids from the Roots of Vicia faba L. (Fabaceae): Structural Characterization, Cytotoxic Effects, and Molecular Docking

Chemistry &Biodiversity, EarlyView.
ABSTRACT The chemical study of the ethanolic extract from the roots of Vicia faba led to the isolation of two isoflavonoids, alfalone and 8‐O‐methylretusine, as well as a mixture of rotenoids, including clitoriacetal and clitoriacetal B, the latter of which is reported for the first time.
Victor Menezes Sipoloni, João Victor Silva‐Silva, Elthon G. Ferreira, Eric Yoshitaka Lee, João Marcos Batista Junior, Miriam Uemi, Lívia Soman de Medeiros, Paula C. Jimenez, Thiago A. M. Veiga   +8 more
wiley   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

ChemBioChem, Accepted Article.
The ubiquitin (Ub) system governs vital cellular processes in eukaryotic biology through an intricate network of Ub‐protein interactions. While semisynthetic C‐terminal Ub electrophiles (UbEs) are widely used to study Ub transfer and deubiquitinase (Dub) activity, they are limited to probing the active site while leaving other functionally important ...
Chittaranjan Das, Nipuni M. Pannala, Rishi S. Patel, Abhijith Saseendran Anit, Debapriya Bhattacharya, Kristos Negron Teron, Bryon Drown, Rudi Fasan   +7 more
wiley   +1 more source

Hybridization Probes Featuring a Pyrenylpyridine C‐Nucleoside or Its Palladacycle as a Fluorescent Sensor Moiety

ChemBioChem, EarlyView.
When placed in the middle of a double helix as a nucleobase surrogate, pyren‐1‐ylpyridine and its palladacyclic derivative show fluorescence emission sensitive to the identity of the canonical nucleobase opposite to it. Emission of the palladacycle is weaker but the base discrimination stronger, possibly because of Pd(II)‐mediated base pairing.
Dattatraya Uttam Ukale, Tuomas Lönnberg
wiley   +1 more source

Rivalling Self‐Oxidation and Aldehyde Deformylation by a Dinuclear Copper(II)‐Superoxide Complex

ChemCatChem, EarlyView.
A dinuclear Cu2L2‐O2•− reactive intermediate stabilized by a tetradentate N3O ligand set is postulated to be at the origin of aldehyde deformylation via a Baeyer‐Villiger oxidation mechanism, while enabling a radical self‐oxidation cascade in the absence of the substrate.
Andrea Squarcina, Marta Lovisari, Paolo Pirovano, Aidan R. McDonald, Marcella Bonchio   +4 more
wiley   +1 more source

Characterization of Forced Degradants of Tegafur, Gimeracil, and Oteracil Potassium by Liquid Chromatographic-Electrospray Ionization-Mass Spectrometry and Simultaneous Estimation of Triple Combination in Drug Substance and Finished Pharmaceutical Dosage Form. [PDF]

Arch Razi Inst
Pal AK, Raja S.
europepmc   +1 more source

Efficient Synthesis of Porphyrin–Iridium Complex for Enhanced Cocatalyst‐Free Photocatalytic Hydrogen Evolution

ChemCatChem, EarlyView.
The tetra‐coordinated iridium‐motif conjugated porphyrin T‐Ir‐ZnPF, possessing Förster‐type triplet‐to‐singlet energy transfer, produces an efficient cocatalyst‐free photocatalytic hydrogen evolution rate (ηH2) of 5.34 mmol g⁻¹ h⁻¹, whereas hydrogen evolution was not detected for the control porphyrin ZnPF without the iridium‐motif.
Govardhana Babu Bodedla, Muhammad Imran, Jianzhang Zhao, Xunjin Zhu, Wai‐Yeung Wong   +4 more
wiley   +1 more source