Results 91 to 100 of about 291,728 (311)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Electrostatic properties of two-dimensional WSe2 nanostructures [PDF]
, 2016 Recently, two-dimensional transition metal dichalcogenides have intrigued much attention due to their promising applications in optoelectronics. The electrostatic property investigation of WSe2 nanostructures is essential for device application.
Hao, Guolin +13 more
core +1 more source
Engineering a genetically-encoded SHG chromophore by electrostatic targeting to the membrane
Frontiers in Molecular Neuroscience, 2014 Although second harmonic generation (SHG) microscopy provides unique imaging advantages for voltage imaging and other biological applications, genetically-encoded SHG chromophores remain relatively unexplored.
Yuka eJinno +7 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Вестник Северо-Кавказского федерального университета, 2022 The article presents the results of quantum-chemical study of influence of electrochemically activated water on the catalytic activity of proteolytic enzyme subtilisin, producer - Bacillus licheniformis.
Aleksandr Borisenko +3 more
doaj
On the appearance of carboxylates in electrostatic potential maps [PDF]
Protein Science, 2016 AbstractElectron microscopy can provide accurate, high‐resolution images of the distribution of electrostatic potential (ESP) in biological macromolecules. Careful examination of ESP maps that have been published for peptides and proteins at resolution ranging from 1.0 Å to 2.9 Å reveals that the negative charges of carboxylate groups have a profound ...
openaire +2 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Electrostatic manipulation of piezoelectric fibres using a sharp probe electrode in a dielectric liquid: Analysis of the electrohydrodynamic phenomena [PDF]
, 2007 Micro-assembly techniques have been identified as a major technology ‘pillar’ that will underpin further advancements in integrated micro-and nano-systems.
Capria, Ennio
core
Extended Field Interactions in Poisson’s Equation Revision
Applied SciencesThis investigation introduces a new variational approach to refining Poisson’s equation, enabling the inclusion of a broader spectrum of physical phenomena, particularly in the emerging fields of spintronics and the analysis of resonant structures.
Mario J. Pinheiro
doaj +1 more source