Results 91 to 100 of about 8,886,832 (245)

Is the Fluorine in Molecules Dispersive? Is Molecular Electrostatic Potential a Valid Property to Explore Fluorine-Centered Non-Covalent Interactions?

Molecules, 2019
Can two sites of positive electrostatic potential localized on the outer surfaces of two halogen atoms (and especially fluorine) in different molecular domains attract each other to form a non-covalent engagement? The answer, perhaps counterintuitive, is
Arpita Varadwaj, Helder M. Marques, Pradeep R. Varadwaj   +2 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Crystal structure, Hirshfeld surface analysis and DFT study of 2-(2-isopropyl-5-methylcyclohexyloxy)-2-oxoethyl benzoate

Acta Crystallographica Section E: Crystallographic Communications
The title menthol-derived ester, C19H26O4, was synthesized by chloroacetylation of menthol followed by reaction with sodium benzoate. It crystallizes in the Sohncke space group P21 with one molecule in the asymmetric unit.
Zulfiya Khalmuratova, Ugilay Abdurakhmanova, Alimjan Matchanov, Odil Choriyev, Batirbay Torambetov, Alisher Eshimbetov, Jamshid Ashurov   +6 more
doaj   +1 more source

σ-Hole Interactions: Perspectives and Misconceptions

Crystals, 2017
After a brief discussion of the σ-hole concept and the significance of molecular electrostatic potentials in noncovalent interactions, we draw attention to some common misconceptions that are encountered in that context: (1) Since the electrostatic ...
Peter Politzer, Jane S. Murray
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Crystal structure analysis of the biologically active drug molecule riluzole and riluzolium chloride

Acta Crystallographica Section E: Crystallographic Communications, 2019
This study is an investigation into the crystal structure of the biologically active drug molecule riluzole [RZ, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine], C8H5F3N2OS, and its derivative, the riluzolium chloride salt [RZHCl, 2-amino-6 ...
Pradip Kumar Mondal, Athulbabu T, Varun Rao, Deepak Chopra   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Cyclic Voltammetric and Quantum Chemical Studies of a Poly(methionine) Modified Carbon Paste Electrode for Simultaneous Detection of Dopamine and Uric Acid

Chemosensors, 2019
Fabrication of biocompatible electrodes for the investigation of catecholamines is a known challenge. In this work, methionine was chosen as a modifier for fabrication of a biocompatible carbon paste electrode by electropolymerization, through cyclic ...
Bananakere Nanjegowda Chandrashekar, Weizhong Lv, Gururaj Kudur Jayaprakash, Karim Harrath, Louis W.Y. Liu, Bahaddurghatta E. Kumara Swamy   +5 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Nonlinear Waves of a Surface Charge at the Boundary of a Semi-Infinite Cold Plasma in a Constant Magnetic Field

Physics
In this paper, an equation describing nonlinear wave phenomena on the surface of magnetically active plasma in the approximation of the complete homogeneity of processes along the direction of the constant magnetic field is obtained. One of its solutions,
Oleg M. Gradov
doaj   +1 more source