Results 51 to 60 of about 8,886,832 (245)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
DC-dynamic biasing for \u3e 50x switching time improvement in severely underdamped fringing-field electrostatic MEMS actuators [PDF]
, 2012 This paper presents the design and experimental validation of dc-dynamic biasing for \u3e50x switching time improvement in severely underdamped fringing-field electrostatic MEMS actuators.
Small, J. +4 more
core +1 more source
AGOA: A Hydration Procedure and Its Application to the 1-Phenyl-b-Carboline Molecule
Journal of the Brazilian Chemical Society, 2002 A new procedure, named AGOA, has been developed and implemented in a computer program written in FORTRAN 77 to explore the hydration structures of polar solutes using its molecular electrostatic potential (MEP). This procedure can be generalized to polar
Hernandes Marcelo Z. +2 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Publicaciones en Ciencias y Tecnología, 2013 On the four-dimensional sector of an AdS5 warped geometry the standard electromagnetic interaction can be simulated by massive vector fields via the Ghoroku - Nakamura localization mechanism.
Rommel Guerrero, Rafael Omar Rodríguez
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Crystal Structure Prediction and Intermolecular Interaction Study of CL-20/NQ Cocrystal Explosive
四川大学学报. 自然科学版, 2016 Density functional theory was employed to investigate the four structures (a, b, c, d) of CL-20/NQ cocrystal. The intermolecular interaction, explosive property, and crystal structure were analyzed and predicted in this paper.
GOU Rui-Jun +5 more
doaj
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source