Results 51 to 60 of about 219,642 (266)
Elementary particles as elementary particles
Abstract The Z = 0 rule is investigated within a general field theoretic formulation. It is shown that the equivalence of a system with an elementary particle of vanishing wave function renormalization to a direct interaction theory is intimately related to the divergence of the bare mass and the consequent degeneration of the equations of motion ...
openaire +4 more sources
The peace project: creating elementary school peace spaces and places
IntroductionThis pilot case study paper demonstrates how school programming can be aligned and enhanced to better create a climate of peace on an elementary school campus by utilizing an integral peace leadership lens.
Whitney McIntyre Miller +3 more
doaj +1 more source
On Colimits and Elementary Embeddings [PDF]
AbstractWe give a sharper version of a theorem of Rosický, Trnková and Adámek [13], and a new proof of a theorem of Rosický [12], both about colimits in categories of structures. Unlike the original proofs, which use category-theoretic methods, we use set-theoretic arguments involving elementary embeddings given by large cardinals such as α-strongly ...
Joan Bagaria, Andrew D. Brooke-Taylor
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Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
AbstractIn 1861 the physiologist Ernst Brücke (1819–1892) published “The Elementary Organisms,” calling for a major reform of the definition of the animal cell. An English translation of Brücke’s essay is presented here for the first time. In this translation the numbered footnotes 1–9 are Brücke’s own; alphabetical endnotes A–HH are my own annotations,
Ernst Brücke, Daniel Liu
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Elementary Moves on Triangulations [PDF]
It is proved that a triangulation of a polyhedron can always be transformed into any other triangulation of the polyhedron by using only elementary moves. One consequence is that an additive function (valuation) defined only on simplices may always be extended to an additive function on all polyhedra.
Monika Ludwig, Matthias Reitzner
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Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

