Results 51 to 60 of about 8,753,776 (310)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Improving Motivation and Learning Outcomes of Elementary School Students with Multimedia-Based Interactive Media

Profesi Pendidikan Dasar
This study addresses challenges in 21st-century education, particularly the low motivation and academic performance of elementary school students. It investigates the use of multimedia-based interactive learning tools as a solution to improve engagement ...
Devi Afriyuni Yonanda, Islahuddin Islahuddin, Fauziah Aulia Ramadhani, Budi Febriyanto, Dudu Suhandi Saputra, Yuyu Yuliati, Eka Nurhidayat   +6 more
doaj   +1 more source

The importance of elementary sexuality education [PDF]

, 2002
Plan BThe purpose of this paper is to look at the importance of elementary sexuality education in schools as well as look at its effect on children.
Meillier, Jill M.
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Does Social Media Use Affect Elementary Students’ Focus and Learning Achievement? A Study on Indonesian Language Learning

Journal of Education and Teaching
The rapid development of digital technology has integrated social media into students' daily routines, including their learning processes. Despite its potential for enhancing communication and information access, excessive social media use has raised ...
Rahmawati Rahmawati, Aliem Bahri, Magfiratul Inayah, Musfiratul Nur Ramdhani, Muhammad Amin Said   +4 more
doaj   +1 more source

University of Northern Iowa Elementary Teacher Education Senate Meeting Agenda, December 5, 2019 [PDF]

, 2019
Meeting agenda from the Elementary Teacher Education Senate of the University of Northern ...
University of Northern Iowa. Elementary Teacher Education Senate.
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

3D Game-Based Learning Media Using a Deep Learning Approach to Enhance Understanding of Natural and Social Science (IPAS) Concepts

Jurnal Media dan Teknologi Pendidikan
The low level of students’ understanding of the IPAS concept, caused by insufficiently interactive learning and minimal use of digital media, forms the background of this study.
Ni Nengah Sari Jati, I Nyoman Laba Jayanta, I Made Hendra Sukmayasa   +2 more
doaj   +1 more source

University of Northern Iowa Elementary Teacher Education Senate Meeting Minutes, April 18, 2019 [PDF]

, 2019
Meeting minutes from the Elementary Teacher Education Senate of the University of Northern ...
University of Northern Iowa. Elementary Teacher Education Senate.
core  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source