Results 51 to 60 of about 8,219,016 (308)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Other title: Kansas Amended Accountability Workbook

, 2008
Amended June 2008; Kansas' response for meeting the requirements of the No Child Left Behind Act has been incorporated within the workbook.; Submitted to U. S.
Kansas. State Department of Education.
core   +1 more source

An Empirical Study of Reading Comprehension Levels among Elementary School Students Based on Barrett's Taxonomy Framework

Jurnal Pedagogi dan Pembelajaran
Fifth-grade elementary students still show suboptimal reading comprehension, particularly in understanding informative texts that are essential for academic success.
Yuliawati, Dadang Sunendar, Dinn Wahyudin, I Wayan Lasmawan, Budi Febriyanto   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Improving Motivation and Learning Outcomes of Elementary School Students with Multimedia-Based Interactive Media

Profesi Pendidikan Dasar
This study addresses challenges in 21st-century education, particularly the low motivation and academic performance of elementary school students. It investigates the use of multimedia-based interactive learning tools as a solution to improve engagement ...
Devi Afriyuni Yonanda, Islahuddin Islahuddin, Fauziah Aulia Ramadhani, Budi Febriyanto, Dudu Suhandi Saputra, Yuyu Yuliati, Eka Nurhidayat   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Does Social Media Use Affect Elementary Students’ Focus and Learning Achievement? A Study on Indonesian Language Learning

Journal of Education and Teaching
The rapid development of digital technology has integrated social media into students' daily routines, including their learning processes. Despite its potential for enhancing communication and information access, excessive social media use has raised ...
Rahmawati Rahmawati, Aliem Bahri, Magfiratul Inayah, Musfiratul Nur Ramdhani, Muhammad Amin Said   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

3D Game-Based Learning Media Using a Deep Learning Approach to Enhance Understanding of Natural and Social Science (IPAS) Concepts

Jurnal Media dan Teknologi Pendidikan
The low level of students’ understanding of the IPAS concept, caused by insufficiently interactive learning and minimal use of digital media, forms the background of this study.
Ni Nengah Sari Jati, I Nyoman Laba Jayanta, I Made Hendra Sukmayasa   +2 more
doaj   +1 more source