Results 41 to 50 of about 1,288,575 (308)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Learning Fable Texts through Retelling Strategies in Developing Reading Culture for Elementary School Students

Indonesian Journal of Instruction
Reading interest and reading culture are fundamental foundations for strengthening literacy from an early age in elementary school. However, students’ reading habits remain low due to learning methods that are less engaging and fail to actively involve ...
Triyuslia Hayati, Annisa Nadya Salsa Amara, Ghustyan Ghema Ramadhan, Suherli Kusmana, Mudopar Mudopar   +4 more
doaj   +3 more sources

Development of Digital Comic Media Based on Education for Sustainable Development (ESD) to Improve Cultural and Citizenship Literacy of Elementary Students

Jurnal Kependidikan
This research aims to develop digital comics media to increase students’ cultural and citizenship literacy based on Education for Sustainable Development (ESD).
Eka Putri Ramadhany, Mela Darmayanti, Kurniasih Kurniasih, Tatang Syaripudin   +3 more
doaj   +1 more source

An Instrument Development to Measure the Creative Habits of Mind for Prospective Elementary School Teachers

Jurnal Kependidikan, 2023
This study aims to produce an instrument for measuring the creative habits of mind for prospective elementary school teachers in relation to developing creative teaching and learning ideas.
Neni Maulidah, Sapriya Sapriya, Nana Supriatna   +2 more
doaj   +1 more source

Evaluative criteria for elementary school physical education. [PDF]

, 1957
Thesis (Ed.M.)--Boston ...
Bergstrom, Merrill Stanley
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Environmental Education should go further [PDF]

, 2000
Outlines Scottish national policy guidelines on 'education for sustainable development' (environmental education for ages 5-14) and implications for primary schools. Describes a 2-year project in which a research team helped staff at an elementary school
Laing, Moira, McNaughton, Marie Jeanne
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Art to empower: designing and implementing a contemporary visual culture art education for urban elementary institutions with implications for classroom practice [PDF]

, 2009
The following paper offers a comprehensive historiography of the curricular trends and approaches for the teaching of elementary visual arts within the discourse of Art Education. The exploration begins with an overview of the modernist, Discipline Based
Pleszkiewicz, Tamara C.
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source