Results 61 to 70 of about 1,288,575 (308)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

‘Truth or Dare’ Media Based on Game Learning for Science Learning in Fifth-Grade Elementary Students

open access: yesMimbar Ilmu
This study was motivated by the low interest and participation of students in Social Science learning (IPAS) on the topic “My Proud Region”, which was caused by the use of monotonous and less interactive teaching methods.
Putu Jessie Ardi Sudira   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

The Nature of Differentiated Learning in The Perspective of Constructivist Educational Philosophy: A Systematic Literature Review

open access: yesJurnal Kependidikan
This study aims to examine differentiated learning from the perspective of constructivist educational philosophy, namely the application of differentiated learning and the relationship between constructivism and differentiated learning.
Anggi Umayrah   +4 more
doaj   +1 more source

The effectiveness of artificial intelligence in gamification assessment for meansuring learning outcomes of elementary school students at SDN Kemayoran 2 Bangkalan [PDF]

open access: yesEPJ Web of Conferences
This study aims to analyze the effectiveness of applying Artificial Intelligence (AI) in assessment gamification to improve student learning outcomes at SDN Kemayoran 2 Bangkalan.
Dian Rahmawati Ika   +2 more
doaj   +1 more source

State of Elementary Education in Public Schools of Gujarat: A Study of Schools Run by the Bharuch Municipality [PDF]

open access: yes
In India the 73rd and 74th constitutional amendments have given powers and responsibility of achieving the goal of Universal Elementary Education (UEE) to the local body governments.
Raj, Madhusudan
core   +1 more source

An Unfinished Canvas: Allocating Funding and Instructional Time for Elementary Arts Education [PDF]

open access: yes, 2008
An Unfinished Canvas found that California's elementary schools face unique challenges inproviding all students with sequential, standards-based arts education.
Ashley Z. Campbell   +5 more
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

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